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Widespread microRNA degradation elements in target mRNAs can assist the encoded proteins

Binding of microRNAs (miRNAs) to mRNAs normally results in post-transcriptional repression of gene expression. However, extensive base-pairing between miRNAs and target RNAs can trigger miRNA degradation, a phenomenon called target RNA-directed miRNA degradation (TDMD). Here, we systematically analy...

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Detalles Bibliográficos
Autores principales: Li, Lu, Sheng, Peike, Li, Tianqi, Fields, Christopher J., Hiers, Nicholas M., Wang, Yuzhi, Li, Jianping, Guardia, Casey M., Licht, Jonathan D., Xie, Mingyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653786/
https://www.ncbi.nlm.nih.gov/pubmed/34819352
http://dx.doi.org/10.1101/gad.348874.121