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The evolution of metazoan shelterin

The mammalian telomeric shelterin complex—comprised of TRF1, TRF2, Rap1, TIN2, TPP1, and POT1—blocks the DNA damage response at chromosome ends and interacts with telomerase and the CST complex to regulate telomere length. The evolutionary origins of shelterin are unclear, partly because unicellular...

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Detalles Bibliográficos
Autores principales:	Myler, Logan R., Kinzig, Charles G., Sasi, Nanda K., Zakusilo, George, Cai, Sarah W., de Lange, Titia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653790/ https://www.ncbi.nlm.nih.gov/pubmed/34764137 http://dx.doi.org/10.1101/gad.348835.121

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