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Cholesterol metabolism pathways – are the intermediates more important than the products?
Every cell in vertebrates possesses the machinery to synthesise cholesterol and to metabolise it. The major route of cholesterol metabolism is conversion to bile acids. Bile acids themselves are interesting molecules being ligands to nuclear and G protein‐coupled receptors, but perhaps the intermedi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653896/ https://www.ncbi.nlm.nih.gov/pubmed/33506652 http://dx.doi.org/10.1111/febs.15727 |
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author | Wang, Yuqin Yutuc, Eylan Griffiths, William J. |
author_facet | Wang, Yuqin Yutuc, Eylan Griffiths, William J. |
author_sort | Wang, Yuqin |
collection | PubMed |
description | Every cell in vertebrates possesses the machinery to synthesise cholesterol and to metabolise it. The major route of cholesterol metabolism is conversion to bile acids. Bile acids themselves are interesting molecules being ligands to nuclear and G protein‐coupled receptors, but perhaps the intermediates in the bile acid biosynthesis pathways are even more interesting and equally important. Here, we discuss the biological activity of the different intermediates generated in the various bile acid biosynthesis pathways. We put forward the hypothesis that the acidic pathway of bile acid biosynthesis has primary evolved to generate signalling molecules and its utilisation by hepatocytes provides an added bonus of producing bile acids to aid absorption of lipids in the intestine. |
format | Online Article Text |
id | pubmed-8653896 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86538962021-12-20 Cholesterol metabolism pathways – are the intermediates more important than the products? Wang, Yuqin Yutuc, Eylan Griffiths, William J. FEBS J State‐of‐the‐Art Reviews Every cell in vertebrates possesses the machinery to synthesise cholesterol and to metabolise it. The major route of cholesterol metabolism is conversion to bile acids. Bile acids themselves are interesting molecules being ligands to nuclear and G protein‐coupled receptors, but perhaps the intermediates in the bile acid biosynthesis pathways are even more interesting and equally important. Here, we discuss the biological activity of the different intermediates generated in the various bile acid biosynthesis pathways. We put forward the hypothesis that the acidic pathway of bile acid biosynthesis has primary evolved to generate signalling molecules and its utilisation by hepatocytes provides an added bonus of producing bile acids to aid absorption of lipids in the intestine. John Wiley and Sons Inc. 2021-02-17 2021-06 /pmc/articles/PMC8653896/ /pubmed/33506652 http://dx.doi.org/10.1111/febs.15727 Text en © 2021 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | State‐of‐the‐Art Reviews Wang, Yuqin Yutuc, Eylan Griffiths, William J. Cholesterol metabolism pathways – are the intermediates more important than the products? |
title | Cholesterol metabolism pathways – are the intermediates more important than the products? |
title_full | Cholesterol metabolism pathways – are the intermediates more important than the products? |
title_fullStr | Cholesterol metabolism pathways – are the intermediates more important than the products? |
title_full_unstemmed | Cholesterol metabolism pathways – are the intermediates more important than the products? |
title_short | Cholesterol metabolism pathways – are the intermediates more important than the products? |
title_sort | cholesterol metabolism pathways – are the intermediates more important than the products? |
topic | State‐of‐the‐Art Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8653896/ https://www.ncbi.nlm.nih.gov/pubmed/33506652 http://dx.doi.org/10.1111/febs.15727 |
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