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Twenty-Four–Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals
Central (aortic) systolic blood pressure (cSBP) is the pressure seen by the heart, the brain, and the kidneys. If properly measured, cSBP is closer associated with hypertension-mediated organ damage and prognosis, as compared with brachial SBP (bSBP). We investigated 24-hour profiles of bSBP and cSB...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654125/ https://www.ncbi.nlm.nih.gov/pubmed/34775789 http://dx.doi.org/10.1161/HYPERTENSIONAHA.121.17765 |
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author | Weber, Thomas Protogerou, Athanase D. Agharazii, Mohsen Argyris, Antonis Aoun Bahous, Sola Banegas, Jose R. Binder, Ronald K. Blacher, Jacques Araujo Brandao, Andréa Cruz, Juan J. Danninger, Kathrin Giannatasio, Cristina Graciani, Auxiliadora Hametner, Bernhard Jankowski, Piotr Li, Yan Maloberti, Alessandro Mayer, Christopher C. McDonnell, Barry J. McEniery, Carmel M. Antonio Mota Gomes, Marco Machado Gomes, Annelise Lorenza Muiesan, Maria Nemcsik, Janos Paini, Anna Rodilla, Enrique Schutte, Aletta E. Sfikakis, Petros P. Terentes-Printzios, Dimitrios Vallée, Alexandre Vlachopoulos, Charalambos Ware, Lisa Wilkinson, Ian Zweiker, Robert Sharman, James E. Wassertheurer, Siegfried |
author_facet | Weber, Thomas Protogerou, Athanase D. Agharazii, Mohsen Argyris, Antonis Aoun Bahous, Sola Banegas, Jose R. Binder, Ronald K. Blacher, Jacques Araujo Brandao, Andréa Cruz, Juan J. Danninger, Kathrin Giannatasio, Cristina Graciani, Auxiliadora Hametner, Bernhard Jankowski, Piotr Li, Yan Maloberti, Alessandro Mayer, Christopher C. McDonnell, Barry J. McEniery, Carmel M. Antonio Mota Gomes, Marco Machado Gomes, Annelise Lorenza Muiesan, Maria Nemcsik, Janos Paini, Anna Rodilla, Enrique Schutte, Aletta E. Sfikakis, Petros P. Terentes-Printzios, Dimitrios Vallée, Alexandre Vlachopoulos, Charalambos Ware, Lisa Wilkinson, Ian Zweiker, Robert Sharman, James E. Wassertheurer, Siegfried |
author_sort | Weber, Thomas |
collection | PubMed |
description | Central (aortic) systolic blood pressure (cSBP) is the pressure seen by the heart, the brain, and the kidneys. If properly measured, cSBP is closer associated with hypertension-mediated organ damage and prognosis, as compared with brachial SBP (bSBP). We investigated 24-hour profiles of bSBP and cSBP, measured simultaneously using Mobilograph devices, in 2423 untreated adults (1275 women; age, 18–94 years), free from overt cardiovascular disease, aiming to develop reference values and to analyze daytime-nighttime variability. Central SBP was assessed, using brachial waveforms, calibrated with mean arterial pressure (MAP)/diastolic BP (cSBP(MAP/DBPcal)), or bSBP/diastolic blood pressure (cSBP(SBP/DBPcal)), and a validated transfer function, resulting in 144 509 valid brachial and 130 804 valid central measurements. Averaged 24-hour, daytime, and nighttime brachial BP across all individuals was 124/79, 126/81, and 116/72 mm Hg, respectively. Averaged 24-hour, daytime, and nighttime values for cSBP(MAP/DBPcal) were 128, 128, and 125 mm Hg and 115, 117, and 107 mm Hg for cSBP(SBP/DBPcal), respectively. We pragmatically propose as upper normal limit for 24-hour cSBP(MAP/DBPcal) 135 mm Hg and for 24-hour cSBP(SBP/DBPcal) 120 mm Hg. bSBP dipping (nighttime-daytime/daytime SBP) was −10.6 % in young participants and decreased with increasing age. Central SBP(SBP/DBPcal) dipping was less pronounced (−8.7% in young participants). In contrast, cSBP(MAP/DBPcal) dipping was completely absent in the youngest age group and less pronounced in all other participants. These data may serve for comparison in various diseases and have potential implications for refining hypertension diagnosis and management. The different dipping behavior of bSBP versus cSBP requires further investigation. |
format | Online Article Text |
id | pubmed-8654125 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-86541252021-12-09 Twenty-Four–Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals Weber, Thomas Protogerou, Athanase D. Agharazii, Mohsen Argyris, Antonis Aoun Bahous, Sola Banegas, Jose R. Binder, Ronald K. Blacher, Jacques Araujo Brandao, Andréa Cruz, Juan J. Danninger, Kathrin Giannatasio, Cristina Graciani, Auxiliadora Hametner, Bernhard Jankowski, Piotr Li, Yan Maloberti, Alessandro Mayer, Christopher C. McDonnell, Barry J. McEniery, Carmel M. Antonio Mota Gomes, Marco Machado Gomes, Annelise Lorenza Muiesan, Maria Nemcsik, Janos Paini, Anna Rodilla, Enrique Schutte, Aletta E. Sfikakis, Petros P. Terentes-Printzios, Dimitrios Vallée, Alexandre Vlachopoulos, Charalambos Ware, Lisa Wilkinson, Ian Zweiker, Robert Sharman, James E. Wassertheurer, Siegfried Hypertension Original Articles Central (aortic) systolic blood pressure (cSBP) is the pressure seen by the heart, the brain, and the kidneys. If properly measured, cSBP is closer associated with hypertension-mediated organ damage and prognosis, as compared with brachial SBP (bSBP). We investigated 24-hour profiles of bSBP and cSBP, measured simultaneously using Mobilograph devices, in 2423 untreated adults (1275 women; age, 18–94 years), free from overt cardiovascular disease, aiming to develop reference values and to analyze daytime-nighttime variability. Central SBP was assessed, using brachial waveforms, calibrated with mean arterial pressure (MAP)/diastolic BP (cSBP(MAP/DBPcal)), or bSBP/diastolic blood pressure (cSBP(SBP/DBPcal)), and a validated transfer function, resulting in 144 509 valid brachial and 130 804 valid central measurements. Averaged 24-hour, daytime, and nighttime brachial BP across all individuals was 124/79, 126/81, and 116/72 mm Hg, respectively. Averaged 24-hour, daytime, and nighttime values for cSBP(MAP/DBPcal) were 128, 128, and 125 mm Hg and 115, 117, and 107 mm Hg for cSBP(SBP/DBPcal), respectively. We pragmatically propose as upper normal limit for 24-hour cSBP(MAP/DBPcal) 135 mm Hg and for 24-hour cSBP(SBP/DBPcal) 120 mm Hg. bSBP dipping (nighttime-daytime/daytime SBP) was −10.6 % in young participants and decreased with increasing age. Central SBP(SBP/DBPcal) dipping was less pronounced (−8.7% in young participants). In contrast, cSBP(MAP/DBPcal) dipping was completely absent in the youngest age group and less pronounced in all other participants. These data may serve for comparison in various diseases and have potential implications for refining hypertension diagnosis and management. The different dipping behavior of bSBP versus cSBP requires further investigation. Lippincott Williams & Wilkins 2021-11-15 2022-01 /pmc/articles/PMC8654125/ /pubmed/34775789 http://dx.doi.org/10.1161/HYPERTENSIONAHA.121.17765 Text en © 2021 The Authors. https://creativecommons.org/licenses/by-nc-nd/4.0/Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections. |
spellingShingle | Original Articles Weber, Thomas Protogerou, Athanase D. Agharazii, Mohsen Argyris, Antonis Aoun Bahous, Sola Banegas, Jose R. Binder, Ronald K. Blacher, Jacques Araujo Brandao, Andréa Cruz, Juan J. Danninger, Kathrin Giannatasio, Cristina Graciani, Auxiliadora Hametner, Bernhard Jankowski, Piotr Li, Yan Maloberti, Alessandro Mayer, Christopher C. McDonnell, Barry J. McEniery, Carmel M. Antonio Mota Gomes, Marco Machado Gomes, Annelise Lorenza Muiesan, Maria Nemcsik, Janos Paini, Anna Rodilla, Enrique Schutte, Aletta E. Sfikakis, Petros P. Terentes-Printzios, Dimitrios Vallée, Alexandre Vlachopoulos, Charalambos Ware, Lisa Wilkinson, Ian Zweiker, Robert Sharman, James E. Wassertheurer, Siegfried Twenty-Four–Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals |
title | Twenty-Four–Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals |
title_full | Twenty-Four–Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals |
title_fullStr | Twenty-Four–Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals |
title_full_unstemmed | Twenty-Four–Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals |
title_short | Twenty-Four–Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals |
title_sort | twenty-four–hour central (aortic) systolic blood pressure: reference values and dipping patterns in untreated individuals |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654125/ https://www.ncbi.nlm.nih.gov/pubmed/34775789 http://dx.doi.org/10.1161/HYPERTENSIONAHA.121.17765 |
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