RB depletion is required for the continuous growth of tumors initiated by loss of RB

The retinoblastoma (RB) tumor suppressor is functionally inactivated in a wide range of human tumors where this inactivation promotes tumorigenesis in part by allowing uncontrolled proliferation. RB has been extensively studied, but its mechanisms of action in normal and cancer cells remain only par...

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Detalles Bibliográficos
Autores principales: Doan, Alex, Arand, Julia, Gong, Diana, Drainas, Alexandros P., Shue, Yan Ting, Lee, Myung Chang, Zhang, Shuyuan, Walter, David M., Chaikovsky, Andrea C., Feldser, David M., Vogel, Hannes, Dow, Lukas E., Skotheim, Jan M., Sage, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654178/
https://www.ncbi.nlm.nih.gov/pubmed/34879057
http://dx.doi.org/10.1371/journal.pgen.1009941

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