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Tenofovir disoproxil fumarate directly ameliorates liver fibrosis by inducing hepatic stellate cell apoptosis via downregulation of PI3K/Akt/mTOR signaling pathway

BACKGROUND: Antifibrotic agent for the treatment of liver fibrosis has not been developed so far. Long term treatment of chronic hepatitis B patients with antiviral drugs tenofovir disoproxil fumarate (TDF) and entecavir (ETV) results in the regression of liver fibrosis, but the underlying mechanism...

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Detalles Bibliográficos
Autores principales:	Lee, Sung Won, Kim, Sung Min, Hur, Wonhee, Kang, Byung-Yoon, Lee, Hae Lim, Nam, Heechul, Yoo, Sun Hong, Sung, Pil Soo, Kwon, Jung Hyun, Jang, Jeong Won, Kim, Seong-Jun, Yoon, Seung Kew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654182/ https://www.ncbi.nlm.nih.gov/pubmed/34879114 http://dx.doi.org/10.1371/journal.pone.0261067

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