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Deciphering conformational selectivity in the A(2A) adenosine G protein-coupled receptor by free energy simulations
Transmembranal G Protein-Coupled Receptors (GPCRs) transduce extracellular chemical signals to the cell, via conformational change from a resting (inactive) to an active (canonically bound to a G-protein) conformation. Receptor activation is normally modulated by extracellular ligand binding, but mu...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654218/ https://www.ncbi.nlm.nih.gov/pubmed/34818333 http://dx.doi.org/10.1371/journal.pcbi.1009152 |