Cargando…

Robust HIV-specific CD4(+) and CD8(+) T-cell responses distinguish elite control in adolescents living with HIV from viremic nonprogressors

BACKGROUND: Elite controllers are therapy-naive individuals living with HIV capable of spontaneous control of plasma viraemia for at least a year. Although viremic nonprogressors are more common in vertical HIV-infection than in adults’ infection, elite control has been rarely characterized in the p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vieira, Vinicius A., Millar, Jane, Adland, Emily, Muenchhoff, Maximilian, Roider, Julia, Guash, Claudia Fortuny, Peluso, Denise, Thomé, Beatriz, Garcia-Guerrero, Maria C., Puertas, Mari C., Bamford, Alasdair, Brander, Christian, Carrington, Mary, Martinez-Picado, Javier, Frater, John, Tudor-Williams, Gareth, Goulder, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2022
Materias:	Epidemiology and Social
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654249/ https://www.ncbi.nlm.nih.gov/pubmed/34581306 http://dx.doi.org/10.1097/QAD.0000000000003078

Ejemplares similares

Viral and Cellular Factors Leading to the Loss of CD4 Homeostasis in HIV-1 Viremic Nonprogressors
por: Colomer-Lluch, Marta, et al.
Publicado: (2022)

An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults
por: Vieira, Vinicius A., et al.
Publicado: (2021)

Control of HIV-1 Pathogenesis in Viremic Nonprogressors Is Independent of Gag-Specific Cytotoxic T Lymphocyte Responses
por: Salgado, Maria, et al.
Publicado: (2018)

Strong sex bias in elite control of paediatric HIV infection
por: Vieira, Vinicius A., et al.
Publicado: (2019)

Increased Regulatory T-Cell Activity and Enhanced T-Cell Homeostatic Signaling in Slow Progressing HIV-infected Children
por: Roider, Julia, et al.
Publicado: (2019)

Pediatric HIV Long-Term Nonprogressors
por: Rimawi, B. H., et al.
Publicado: (2014)

Slow progression of pediatric HIV associates with early CD8(+) T cell PD-1 expression and a stem-like phenotype
por: Vieira, Vinicius, et al.
Publicado: (2023)

Recovery of effective HIV-specific CD4(+) T-cell activity following antiretroviral therapy in paediatric infection requires sustained suppression of viraemia
por: Adland, Emily, et al.
Publicado: (2018)

Plasma IL-5 but Not CXCL13 Correlates With Neutralization Breadth in HIV-Infected Children
por: Roider, Julia, et al.
Publicado: (2019)

Paediatric non-progression following grandmother-to-child HIV transmission
por: Tsai, M.-H., et al.
Publicado: (2016)

Early Initiation of Antiretroviral Therapy Following In Utero HIV Infection Is Associated With Low Viral Reservoirs but Other Factors Determine Viral Rebound
por: Millar, Jane R, et al.
Publicado: (2021)

New Clues to Understanding HIV Nonprogressors: Low Cholesterol Blocks HIV Trans Infection
por: Prasad, Vinayaka R., et al.
Publicado: (2014)

Inefficient HIV-1 trans Infection of CD4(+) T Cells by Macrophages from HIV-1 Nonprogressors Is Associated with Altered Membrane Cholesterol and DC-SIGN
por: DeLucia, Diana C., et al.
Publicado: (2018)

Thyroid cancer in a long-term nonprogressor HIV-1 infection
por: Phatak, Uday A., et al.
Publicado: (2015)

Alterations in Cholesterol Metabolism Restrict HIV-1 Trans Infection in Nonprogressors
por: Rappocciolo, Giovanna, et al.
Publicado: (2014)

Differential Pathogen-Specific Immune Reconstitution in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Children
por: Muenchhoff, Maximilian, et al.
Publicado: (2019)

Autophagy plays an important role in the containment of HIV-1 in nonprogressor-infected patients
por: Nardacci, Roberta, et al.
Publicado: (2014)

HIV-1 Subtype C-Infected Children with Exceptional Neutralization Breadth Exhibit Polyclonal Responses Targeting Known Epitopes
por: Ditse, Zanele, et al.
Publicado: (2018)

Elite and viremic HIV-1 controllers in West Africa
por: N’takpé, Jean Baptiste, et al.
Publicado: (2022)

CD32-RNA Co-localizes with HIV-RNA in CD3+ Cells Found within Gut Tissues from Viremic and ART-Suppressed Individuals
por: Vásquez, Joshua J., et al.
Publicado: (2019)

Differential Immunodominance Hierarchy of CD8(+) T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection
por: Adland, Emily, et al.
Publicado: (2018)

Prevalence of Premalignant Cervical Lesions in Women With a Long-term Nonprogressor or HIV Controller Phenotype
por: McLeod, Katherine E., et al.
Publicado: (2014)

CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1(+) viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion
por: Correa-Rocha, Rafael, et al.
Publicado: (2018)

Limited HIV Infection of Central Memory and Stem Cell Memory CD4+ T Cells Is Associated with Lack of Progression in Viremic Individuals
por: Klatt, Nichole R., et al.
Publicado: (2014)

High Levels of TRIM5α Are Associated with Xenophagy in HIV-1-Infected Long-Term Nonprogressors
por: Ciccosanti, Fabiola, et al.
Publicado: (2021)

Mechanism of Viral Suppression among HIV Elite Controllers and Long-Term Nonprogressors in Nigeria and South Africa
por: Ahmed, Rahaman Ademolu, et al.
Publicado: (2022)

High-Frequency, Functional HIV-Specific T-Follicular Helper and Regulatory Cells Are Present Within Germinal Centers in Children but Not Adults
por: Roider, Julia, et al.
Publicado: (2018)

Immunity to HIV in Early Life
por: Muenchhoff, Maximilian, et al.
Publicado: (2014)

Different Immunological Phenotypes Associated with Preserved CD4+ T Cell Counts in HIV-Infected Controllers and Viremic Long Term Non-Progressors
por: Gaardbo, Julie Christine, et al.
Publicado: (2013)

HIGH-FREQUENCY failure of combination antiretroviral therapy in paediatric HIV infection is associated with unmet maternal needs causing maternal NON-ADHERENCE
por: Millar, Jane R., et al.
Publicado: (2020)

Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection
por: Muenchhoff, M., et al.
Publicado: (2020)

Thirty Years with HIV Infection—Nonprogression Is Still Puzzling: Lessons to Be Learned from Controllers and Long-Term Nonprogressors
por: Gaardbo, Julie C., et al.
Publicado: (2012)

Low levels of anti-MPER antibodies are detectable in viremic HIV infected
por: Carrillo, J, et al.
Publicado: (2012)

Mechanisms of Virologic Control and Clinical Characteristics of HIV+ Elite/Viremic Controllers
por: Gonzalo-Gil, Elena, et al.
Publicado: (2017)

Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection
por: Adland, Emily, et al.
Publicado: (2015)

Role of HIV-specific CD8(+) T cells in pediatric HIV cure strategies after widespread early viral escape
por: Leitman, Ellen M., et al.
Publicado: (2017)

Viral Characteristics Associated with the Clinical Nonprogressor Phenotype Are Inherited by Viruses from a Cluster of HIV-1 Elite Controllers
por: Casado, Concepción, et al.
Publicado: (2018)

Relationships of PBMC microRNA expression, plasma viral load, and CD4+ T-cell count in HIV-1-infected elite suppressors and viremic patients
por: Witwer, Kenneth W, et al.
Publicado: (2012)

Viremic HIV Infected Individuals with High CD4 T Cells and Functional Envelope Proteins Show Anti-gp41 Antibodies with Unique Specificity and Function
por: Curriu, Marta, et al.
Publicado: (2012)

Sustained Viremic Control in HIV-Infected Patient: Case Report from Nepal
por: Khadka, Sundar, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_5msn9s00o99r6rtkgdormedqd7