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Protective role of melatonin against adipose-hepatic metabolic comorbidities in experimentally induced obese rat model
BACKGROUND: Adipose and hepatic metabolic dysfunctions are critical comorbidities that also aggravate insulin resistance in obese individuals. Melatonin is a low-cost agent and previous studies suggest that its use may promote metabolic health. However, its effects on some comorbidities associated w...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654266/ https://www.ncbi.nlm.nih.gov/pubmed/34879109 http://dx.doi.org/10.1371/journal.pone.0260546 |
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author | Obayemi, Mary J. Akintayo, Christopher O. Oniyide, Adesola A. Aturamu, Ayodeji Badejogbin, Olabimpe C. Atuma, Chukwubueze L. Saidi, Azeezat O. Mahmud, Hadiza Olaniyi, Kehinde S. |
author_facet | Obayemi, Mary J. Akintayo, Christopher O. Oniyide, Adesola A. Aturamu, Ayodeji Badejogbin, Olabimpe C. Atuma, Chukwubueze L. Saidi, Azeezat O. Mahmud, Hadiza Olaniyi, Kehinde S. |
author_sort | Obayemi, Mary J. |
collection | PubMed |
description | BACKGROUND: Adipose and hepatic metabolic dysfunctions are critical comorbidities that also aggravate insulin resistance in obese individuals. Melatonin is a low-cost agent and previous studies suggest that its use may promote metabolic health. However, its effects on some comorbidities associated with obesity are unknown. Herein, we investigated the hypothesis that melatonin supplementation would attenuate adipose-hepatic metabolic dysfunction in high fat diet (HFD)-induced obesity in male Wistar rats. MATERIALS AND METHODS: Twenty-four adult male Wistar rats (n = 6/group) were used: Control group received vehicle (normal saline), obese group received 40% high fat diet, melatonin-treated group received 4 mg/kg of melatonin, and obese plus melatonin group received 40% HFD and melatonin. The treatment lasted for 12 weeks. RESULTS: HFD caused increased food intake, body weight, insulin level, insulin resistance and plasma and liver lipid but decreased adipose lipid. In addition, HFD also increased plasma, adipose and liver malondialdehyde, IL-6, uric acid and decreased Glucose-6-phosphate dehydrogenase, glutathione, nitric oxide and circulating obestatin concentration. However, these deleterious effects except food intake were attenuated when supplemented with melatonin. CONCLUSION: Taken together, the present results indicate that HFD exposure causes adipose-hepatic metabolic disturbance in obese animals, which are accompanied by oxidative stress and inflammation. In addition, the present results suggest that melatonin supplementation attenuates adipose-hepatic metabolic dysfunction, accompanying obesity by suppression of oxidative stress/inflammation-dependent mechanism and increasing circulating obestatin. |
format | Online Article Text |
id | pubmed-8654266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-86542662021-12-09 Protective role of melatonin against adipose-hepatic metabolic comorbidities in experimentally induced obese rat model Obayemi, Mary J. Akintayo, Christopher O. Oniyide, Adesola A. Aturamu, Ayodeji Badejogbin, Olabimpe C. Atuma, Chukwubueze L. Saidi, Azeezat O. Mahmud, Hadiza Olaniyi, Kehinde S. PLoS One Research Article BACKGROUND: Adipose and hepatic metabolic dysfunctions are critical comorbidities that also aggravate insulin resistance in obese individuals. Melatonin is a low-cost agent and previous studies suggest that its use may promote metabolic health. However, its effects on some comorbidities associated with obesity are unknown. Herein, we investigated the hypothesis that melatonin supplementation would attenuate adipose-hepatic metabolic dysfunction in high fat diet (HFD)-induced obesity in male Wistar rats. MATERIALS AND METHODS: Twenty-four adult male Wistar rats (n = 6/group) were used: Control group received vehicle (normal saline), obese group received 40% high fat diet, melatonin-treated group received 4 mg/kg of melatonin, and obese plus melatonin group received 40% HFD and melatonin. The treatment lasted for 12 weeks. RESULTS: HFD caused increased food intake, body weight, insulin level, insulin resistance and plasma and liver lipid but decreased adipose lipid. In addition, HFD also increased plasma, adipose and liver malondialdehyde, IL-6, uric acid and decreased Glucose-6-phosphate dehydrogenase, glutathione, nitric oxide and circulating obestatin concentration. However, these deleterious effects except food intake were attenuated when supplemented with melatonin. CONCLUSION: Taken together, the present results indicate that HFD exposure causes adipose-hepatic metabolic disturbance in obese animals, which are accompanied by oxidative stress and inflammation. In addition, the present results suggest that melatonin supplementation attenuates adipose-hepatic metabolic dysfunction, accompanying obesity by suppression of oxidative stress/inflammation-dependent mechanism and increasing circulating obestatin. Public Library of Science 2021-12-08 /pmc/articles/PMC8654266/ /pubmed/34879109 http://dx.doi.org/10.1371/journal.pone.0260546 Text en © 2021 Obayemi et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Obayemi, Mary J. Akintayo, Christopher O. Oniyide, Adesola A. Aturamu, Ayodeji Badejogbin, Olabimpe C. Atuma, Chukwubueze L. Saidi, Azeezat O. Mahmud, Hadiza Olaniyi, Kehinde S. Protective role of melatonin against adipose-hepatic metabolic comorbidities in experimentally induced obese rat model |
title | Protective role of melatonin against adipose-hepatic metabolic
comorbidities in experimentally induced obese rat model |
title_full | Protective role of melatonin against adipose-hepatic metabolic
comorbidities in experimentally induced obese rat model |
title_fullStr | Protective role of melatonin against adipose-hepatic metabolic
comorbidities in experimentally induced obese rat model |
title_full_unstemmed | Protective role of melatonin against adipose-hepatic metabolic
comorbidities in experimentally induced obese rat model |
title_short | Protective role of melatonin against adipose-hepatic metabolic
comorbidities in experimentally induced obese rat model |
title_sort | protective role of melatonin against adipose-hepatic metabolic
comorbidities in experimentally induced obese rat model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654266/ https://www.ncbi.nlm.nih.gov/pubmed/34879109 http://dx.doi.org/10.1371/journal.pone.0260546 |
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