Mitochondrial uncoupling protein 1 antagonizes atherosclerosis by blocking NLRP3 inflammasome–dependent interleukin-1β production

Mitochondrial uncoupling protein 1 (UCP1) is the hallmark of brown adipocytes responsible for cold- and diet-induced thermogenesis. Here, we report a previously unidentified role of UCP1 in maintaining vascular health through its anti-inflammatory actions possibly in perivascular adipose tissue. UCP...

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Detalles Bibliográficos
Autores principales: Gu, Ping, Hui, Xiaoyan, Zheng, Qiantao, Gao, Yuan, Jin, Leigang, Jiang, Weimin, Zhou, Changsheng, Liu, Tianxia, Huang, Yu, Liu, Qing, Nie, Tao, Wang, Yanfang, Wang, Yu, Zhao, Jianguo, Xu, Aimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654294/
https://www.ncbi.nlm.nih.gov/pubmed/34878840
http://dx.doi.org/10.1126/sciadv.abl4024

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