Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2

There is a need for additional rapidly scalable, low-cost vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to achieve global vaccination. Aluminum hydroxide (alum) adjuvant is the most widely available vaccine adjuvant but elicits modest humoral responses. We hypothesize...

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Detalles Bibliográficos
Autores principales: Rodrigues, Kristen A., Rodriguez-Aponte, Sergio A., Dalvie, Neil C., Lee, Jeong Hyun, Abraham, Wuhbet, Carnathan, Diane G., Jimenez, Luis E., Ngo, Julia T., Chang, Jason Y. H., Zhang, Zeli, Yu, Jingyou, Chang, Aiquan, Nakao, Catherine, Goodwin, Benjamin, Naranjo, Christopher A., Zhang, Libin, Silva, Murillo, Barouch, Dan H., Silvestri, Guido, Crotty, Shane, Love, J. Christopher, Irvine, Darrell J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654298/
https://www.ncbi.nlm.nih.gov/pubmed/34878851
http://dx.doi.org/10.1126/sciadv.abj6538

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