Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission

Heteroplasmic mitochondrial DNA (mtDNA) mutations are a common cause of inherited disease, but a few recurrent mutations account for the vast majority of new families. The reasons for this are not known. We studied heteroplasmic mice transmitting m.5024C>T corresponding to a human pathogenic muta...

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Detalles Bibliográficos
Autores principales: Zhang, Haixin, Esposito, Marco, Pezet, Mikael G., Aryaman, Juvid, Wei, Wei, Klimm, Florian, Calabrese, Claudia, Burr, Stephen P., Macabelli, Carolina H., Viscomi, Carlo, Saitou, Mitinori, Chiaratti, Marcos R., Stewart, James B., Jones, Nick, Chinnery, Patrick F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654302/
https://www.ncbi.nlm.nih.gov/pubmed/34878831
http://dx.doi.org/10.1126/sciadv.abi5657

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