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Assessing target engagement using proteome-wide solvent shift assays

Recent advances in mass spectrometry (MS) have enabled quantitative proteomics to become a powerful tool in the field of drug discovery, especially when applied toward proteome-wide target engagement studies. Similar to temperature gradients, increasing concentrations of organic solvents stimulate u...

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Detalles Bibliográficos
Autores principales:	Van Vranken, Jonathan G, Li, Jiaming, Mitchell, Dylan C, Navarrete-Perea, José, Gygi, Steven P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654358/ https://www.ncbi.nlm.nih.gov/pubmed/34878405 http://dx.doi.org/10.7554/eLife.70784

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