Cargando…

EGFR transactivates RON to drive oncogenic crosstalk

Crosstalk between different receptor tyrosine kinases (RTKs) is thought to drive oncogenic signaling and allow therapeutic escape. EGFR and RON are two such RTKs from different subfamilies, which engage in crosstalk through unknown mechanisms. We combined high-resolution imaging with biochemical and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Franco Nitta, Carolina, Green, Ellen W, Jhamba, Elton D, Keth, Justine M, Ortiz-Caraveo, Iraís, Grattan, Rachel M, Schodt, David J, Gibson, Aubrey C, Rajput, Ashwani, Lidke, Keith A, Wilson, Bridget S, Steinkamp, Mara P, Lidke, Diane S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654365/ https://www.ncbi.nlm.nih.gov/pubmed/34821550 http://dx.doi.org/10.7554/eLife.63678

Ejemplares similares

Multisite EGFR phosphorylation is regulated by adaptor protein abundances and dimer lifetimes
por: Salazar-Cavazos, Emanuel, et al.
Publicado: (2020)

Spatiotemporal Clustering of Repeated Super-Resolution Localizations via Linear Assignment Problem
por: Schodt, David J., et al.
Publicado: (2021)

Corrigendum: Spatiotemporal Clustering of Repeated Super-Resolution Localizations via Linear Assignment Problem
por: Schodt, David J., et al.
Publicado: (2022)

Combinatorial diversity of Syk recruitment driven by its multivalent engagement with FcεRIγ
por: Travers, Timothy, et al.
Publicado: (2019)

Axial de-scanning using remote focusing in the detection arm of light-sheet microscopy
por: DIBAJI, HASSAN, et al.
Publicado: (2023)

RON kinase isoforms demonstrate variable cell motility in normal cells
por: Greenbaum, Alissa, et al.
Publicado: (2016)

Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer
por: Valley, Christopher C., et al.
Publicado: (2015)

Antigen Geometry Tunes Mast Cell Signaling Through Distinct FcεRI Aggregation and Structural Changes
por: Rinaldi, Derek A., et al.
Publicado: (2023)

Robust, fiducial-free drift correction for super-resolution imaging
por: Wester, Michael J., et al.
Publicado: (2021)

Bcl-2 together with PI3K p110α regulates cell morphology and cell migration
por: Wan, G, et al.
Publicado: (2015)

High-precision estimation of emitter positions using Bayesian grouping of localizations
por: Fazel, Mohamadreza, et al.
Publicado: (2022)

Identification of Regulatory-RNAs for Alternative Splicing of Ron Proto-Oncogene
por: Moon, Heegyum, et al.
Publicado: (2015)

Quantitative cell biology: uniting disciplines to understand the cell
por: Lidke, Diane S.
Publicado: (2017)

Sequential Superresolution Imaging of Multiple Targets Using a Single Fluorophore
por: Valley, Christopher C., et al.
Publicado: (2015)

Significance of the entire C-terminus in biological activities mediated by the RON receptor tyrosine kinase and its oncogenic variant RON160
por: Lu, Yi, et al.
Publicado: (2008)

High-speed single molecule imaging datasets of membrane proteins in rat basophilic leukemia cells
por: Mazloom-Farsibaf, Hanieh, et al.
Publicado: (2020)

Docking of Syk to FcεRI is enhanced by Lyn but limited in duration by SHIP1
por: Kanagy, William K., et al.
Publicado: (2022)

Transactivation of proto-oncogene c-Myc by hepatitis B virus transactivator MHBs(t167)
por: LUN, YONG-ZHI, et al.
Publicado: (2014)

Characterization of the Signaling Modalities of Prostaglandin E2 Receptors EP2 and EP4 Reveals Crosstalk and a Role for Microtubules
por: Vleeshouwers, Ward, et al.
Publicado: (2021)

The H1047R point mutation in p110 alpha changes the morphology of human colon HCT116 cancer cells
por: Wan, G, et al.
Publicado: (2015)

Crosstalk between RON and androgen receptor signaling in the development of castration resistant prostate cancer
por: Batth, Izhar, et al.
Publicado: (2016)

ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand-binding
por: Low-Nam, Shalini T., et al.
Publicado: (2011)

Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics
por: Schwartz, Samantha L., et al.
Publicado: (2017)

Reaching out for signals: filopodia sense EGF and respond by directed retrograde transport of activated receptors
por: Lidke, Diane S., et al.
Publicado: (2005)

Mast Cell Synapses and Exosomes: Membrane Contacts for Information Exchange
por: Carroll-Portillo, Amanda, et al.
Publicado: (2012)

Multi-Color Quantum Dot Tracking Using a High-Speed Hyperspectral Line-Scanning Microscope
por: Cutler, Patrick J., et al.
Publicado: (2013)

Fluorogen-Activating Proteins Provide Tunable Labeling Densities for Tracking FcεRI Independent of IgE
por: Schwartz, Samantha L., et al.
Publicado: (2014)

Sequential super-resolution imaging using DNA strand displacement
por: Pallikkuth, Sandeep, et al.
Publicado: (2018)

The MST1R/RON Tyrosine Kinase in Cancer: Oncogenic Functions and Therapeutic Strategies
por: Cazes, Alex, et al.
Publicado: (2022)

Rapamycin Induces Transactivation of the EGFR and Increases Cell Survival
por: Chaturvedi, Deepti, et al.
Publicado: (2009)

EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis
por: Yang, Xiao-Pei, et al.
Publicado: (2016)

Effect of Phosphorylation on EGFR Dimer Stability Probed by Single-Molecule Dynamics and FRET/FLIM
por: Coban, Oana, et al.
Publicado: (2015)

Ron Knockdown and Ron Monoclonal Antibody IMC-RON8 Sensitize Pancreatic Cancer to Histone Deacetylase Inhibitors (HDACi)
por: Zou, Yi, et al.
Publicado: (2013)

Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction
por: Wang, Ming-Hai, et al.
Publicado: (2013)

Brk/PTK6 Sustains Activated EGFR Signaling through Inhibiting EGFR Degradation and Transactivating EGFR
por: Li, X, et al.
Publicado: (2012)

Transactivation of EGFR by LPS Induces COX-2 Expression in Enterocytes
por: McElroy, Steven J., et al.
Publicado: (2012)

Bulevar del ron
por: Pécheral, Jacques R. (Jacques Renaud), 1908-
Publicado: (1966)

Bulevar del ron
por: Pécheral, Jacques, 1908-
Publicado: (1972)

The healing power of Ron
por: LeBrasseur, Nicole
Publicado: (2003)

Mentors: Ron Kaback
por: Carrasco, Nancy
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_6f4e9h63b1fqg195qoa7a1ncpi