Computational Modeling of Electroencephalography and Functional Magnetic Resonance Imaging Paradigms Indicates a Consistent Loss of Pyramidal Cell Synaptic Gain in Schizophrenia

BACKGROUND: Diminished synaptic gain—the sensitivity of postsynaptic responses to neural inputs—may be a fundamental synaptic pathology in schizophrenia. Evidence for this is indirect, however. Furthermore, it is unclear whether pyramidal cells or interneurons (or both) are affected, or how these de...

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Detalles Bibliográficos
Autores principales: Adams, Rick A., Pinotsis, Dimitris, Tsirlis, Konstantinos, Unruh, Leonhardt, Mahajan, Aashna, Horas, Ana Montero, Convertino, Laura, Summerfelt, Ann, Sampath, Hemalatha, Du, Xiaoming Michael, Kochunov, Peter, Ji, Jie Lisa, Repovs, Grega, Murray, John D., Friston, Karl J., Hong, L. Elliot, Anticevic, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Archival Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654393/
https://www.ncbi.nlm.nih.gov/pubmed/34598786
http://dx.doi.org/10.1016/j.biopsych.2021.07.024

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