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Ndufa6 regulates adipogenic differentiation via Scd1

Obesity and associated complications are becoming a pandemic. Inhibiting adipogenesis is an important intervention for the treatment of obesity. Despite intensive investigations, numerous mechanistic aspects of adipogenesis remain unclear, and many potential therapeutic targets have yet to be discov...

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Autores principales: Zhang, Jingwei, Wang, Wei, Feng, Ninghan, Jiang, Xuan, Zhu, Shenglong, Chen, Yong Q
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654480/
https://www.ncbi.nlm.nih.gov/pubmed/34793269
http://dx.doi.org/10.1080/21623945.2021.2007590
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author Zhang, Jingwei
Wang, Wei
Feng, Ninghan
Jiang, Xuan
Zhu, Shenglong
Chen, Yong Q
author_facet Zhang, Jingwei
Wang, Wei
Feng, Ninghan
Jiang, Xuan
Zhu, Shenglong
Chen, Yong Q
author_sort Zhang, Jingwei
collection PubMed
description Obesity and associated complications are becoming a pandemic. Inhibiting adipogenesis is an important intervention for the treatment of obesity. Despite intensive investigations, numerous mechanistic aspects of adipogenesis remain unclear, and many potential therapeutic targets have yet to be discovered. Transcriptomics and lipidomics approaches were used to explore the functional genes regulating adipogenic differentiation and the potential mechanism in OP9 cells and adipose-derived stem cells. In this study, we found that NADH:ubiquinone oxidoreductase subunit A6 (Ndufa6) participates in the regulation of adipogenic differentiation. Furthermore, we show that the effect of Ndufa6 is mediated through stearoyl-CoA desaturase 1 (Scd1) and demonstrate the inhibitory effect of a SCD1 inhibitor on adipogenesis. Our study broadens the understanding of adipogenic differentiation and offers NDUFA6-SCD1 as a potential therapeutic target for the treatment of obesity.
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spelling pubmed-86544802021-12-09 Ndufa6 regulates adipogenic differentiation via Scd1 Zhang, Jingwei Wang, Wei Feng, Ninghan Jiang, Xuan Zhu, Shenglong Chen, Yong Q Adipocyte Research Paper Obesity and associated complications are becoming a pandemic. Inhibiting adipogenesis is an important intervention for the treatment of obesity. Despite intensive investigations, numerous mechanistic aspects of adipogenesis remain unclear, and many potential therapeutic targets have yet to be discovered. Transcriptomics and lipidomics approaches were used to explore the functional genes regulating adipogenic differentiation and the potential mechanism in OP9 cells and adipose-derived stem cells. In this study, we found that NADH:ubiquinone oxidoreductase subunit A6 (Ndufa6) participates in the regulation of adipogenic differentiation. Furthermore, we show that the effect of Ndufa6 is mediated through stearoyl-CoA desaturase 1 (Scd1) and demonstrate the inhibitory effect of a SCD1 inhibitor on adipogenesis. Our study broadens the understanding of adipogenic differentiation and offers NDUFA6-SCD1 as a potential therapeutic target for the treatment of obesity. Taylor & Francis 2021-12-07 /pmc/articles/PMC8654480/ /pubmed/34793269 http://dx.doi.org/10.1080/21623945.2021.2007590 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Zhang, Jingwei
Wang, Wei
Feng, Ninghan
Jiang, Xuan
Zhu, Shenglong
Chen, Yong Q
Ndufa6 regulates adipogenic differentiation via Scd1
title Ndufa6 regulates adipogenic differentiation via Scd1
title_full Ndufa6 regulates adipogenic differentiation via Scd1
title_fullStr Ndufa6 regulates adipogenic differentiation via Scd1
title_full_unstemmed Ndufa6 regulates adipogenic differentiation via Scd1
title_short Ndufa6 regulates adipogenic differentiation via Scd1
title_sort ndufa6 regulates adipogenic differentiation via scd1
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654480/
https://www.ncbi.nlm.nih.gov/pubmed/34793269
http://dx.doi.org/10.1080/21623945.2021.2007590
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