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Surfactant Stock Optimization for Cost Minimization in Neonatal Intensive Care Units

Surfactant deficiency in newborns is a result of a respiratory insufficiency condition, which is a major cause of illness and death. In terms of maintaining vital functions that require emergency intervention, it is crucial that surfactant is available for treatment upon request. The unknown times b...

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Detalles Bibliográficos
Autores principales: Narli, Müfide, Kokangül, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654546/
https://www.ncbi.nlm.nih.gov/pubmed/34900205
http://dx.doi.org/10.1155/2021/8346584
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author Narli, Müfide
Kokangül, Ali
author_facet Narli, Müfide
Kokangül, Ali
author_sort Narli, Müfide
collection PubMed
description Surfactant deficiency in newborns is a result of a respiratory insufficiency condition, which is a major cause of illness and death. In terms of maintaining vital functions that require emergency intervention, it is crucial that surfactant is available for treatment upon request. The unknown times between patient arrivals and the patients' stochastic weight changes in the hospital cause difficulties in determining the surfactant doses needed. The surfactant dose treatment for patients must be calculated according to the patient's weight. In this study, a mathematical model that minimizes the purchase, order, holding, and waste costs of the surfactant has been developed while finding the optimum vial by considering random variables such as the time between a patient's arrival and weight changes. With cost and demand affecting each other, the model uses a continuous inventory control policy, including calculating how much each preparation and vial should be used for, the reorder point, and the optimum order quantity. Also, the validity of the optimum values obtained with the mathematical model of a 66-bed neonatal intensive care unit in a hospital was tested with real data.
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spelling pubmed-86545462021-12-09 Surfactant Stock Optimization for Cost Minimization in Neonatal Intensive Care Units Narli, Müfide Kokangül, Ali J Healthc Eng Research Article Surfactant deficiency in newborns is a result of a respiratory insufficiency condition, which is a major cause of illness and death. In terms of maintaining vital functions that require emergency intervention, it is crucial that surfactant is available for treatment upon request. The unknown times between patient arrivals and the patients' stochastic weight changes in the hospital cause difficulties in determining the surfactant doses needed. The surfactant dose treatment for patients must be calculated according to the patient's weight. In this study, a mathematical model that minimizes the purchase, order, holding, and waste costs of the surfactant has been developed while finding the optimum vial by considering random variables such as the time between a patient's arrival and weight changes. With cost and demand affecting each other, the model uses a continuous inventory control policy, including calculating how much each preparation and vial should be used for, the reorder point, and the optimum order quantity. Also, the validity of the optimum values obtained with the mathematical model of a 66-bed neonatal intensive care unit in a hospital was tested with real data. Hindawi 2021-12-01 /pmc/articles/PMC8654546/ /pubmed/34900205 http://dx.doi.org/10.1155/2021/8346584 Text en Copyright © 2021 Müfide Narli and Ali Kokangül. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Narli, Müfide
Kokangül, Ali
Surfactant Stock Optimization for Cost Minimization in Neonatal Intensive Care Units
title Surfactant Stock Optimization for Cost Minimization in Neonatal Intensive Care Units
title_full Surfactant Stock Optimization for Cost Minimization in Neonatal Intensive Care Units
title_fullStr Surfactant Stock Optimization for Cost Minimization in Neonatal Intensive Care Units
title_full_unstemmed Surfactant Stock Optimization for Cost Minimization in Neonatal Intensive Care Units
title_short Surfactant Stock Optimization for Cost Minimization in Neonatal Intensive Care Units
title_sort surfactant stock optimization for cost minimization in neonatal intensive care units
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654546/
https://www.ncbi.nlm.nih.gov/pubmed/34900205
http://dx.doi.org/10.1155/2021/8346584
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