Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae

OBJECTIVES: To investigate the efficacy of zidovudine in combination with carbapenems against NDM-1-producing Enterobacteriaceae. METHODS: MICs were determined using the broth microdilution method. The combinatory effects of zidovudine and carbapenems were examined using the chequerboard method and...

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Detalles Bibliográficos
Autores principales: Hu, Yanmin, Coates, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654596/
https://www.ncbi.nlm.nih.gov/pubmed/34120178
http://dx.doi.org/10.1093/jac/dkab184
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author Hu, Yanmin
Coates, Anthony
author_facet Hu, Yanmin
Coates, Anthony
author_sort Hu, Yanmin
collection PubMed
description OBJECTIVES: To investigate the efficacy of zidovudine in combination with carbapenems against NDM-1-producing Enterobacteriaceae. METHODS: MICs were determined using the broth microdilution method. The combinatory effects of zidovudine and carbapenems were examined using the chequerboard method and time–kill analysis. RESULTS: We found that the NDM-1-producing strains were resistant to all carbapenems tested. FIC index from chequerboard assay demonstrated that zidovudine synergized with carbapenems against all the NDM-1 strains. Time–kill analysis demonstrated significant synergistic activity when a low level of zidovudine was combined with meropenem. CONCLUSIONS: Zidovudine in combination with carbapenems produced synergistic activity against NDM-1 Enterobacteriaceae strains in vitro.
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spelling pubmed-86545962021-12-09 Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae Hu, Yanmin Coates, Anthony J Antimicrob Chemother Original Research OBJECTIVES: To investigate the efficacy of zidovudine in combination with carbapenems against NDM-1-producing Enterobacteriaceae. METHODS: MICs were determined using the broth microdilution method. The combinatory effects of zidovudine and carbapenems were examined using the chequerboard method and time–kill analysis. RESULTS: We found that the NDM-1-producing strains were resistant to all carbapenems tested. FIC index from chequerboard assay demonstrated that zidovudine synergized with carbapenems against all the NDM-1 strains. Time–kill analysis demonstrated significant synergistic activity when a low level of zidovudine was combined with meropenem. CONCLUSIONS: Zidovudine in combination with carbapenems produced synergistic activity against NDM-1 Enterobacteriaceae strains in vitro. Oxford University Press 2021-06-13 /pmc/articles/PMC8654596/ /pubmed/34120178 http://dx.doi.org/10.1093/jac/dkab184 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Hu, Yanmin
Coates, Anthony
Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae
title Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae
title_full Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae
title_fullStr Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae
title_full_unstemmed Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae
title_short Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae
title_sort zidovudine enhances activity of carbapenems against ndm-1-producing enterobacteriaceae
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654596/
https://www.ncbi.nlm.nih.gov/pubmed/34120178
http://dx.doi.org/10.1093/jac/dkab184
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