Pseudomonas aeruginosa PcrV Enhances the Nitric Oxide-Mediated Tumoricidal Activity of Tumor-Associated Macrophages via a TLR4/PI3K/AKT/mTOR-Glycolysis-Nitric Oxide Circuit

Tumor-associated macrophages (TAMs), which display a tumor-supportive M2 phenotype, are closely related to tumor growth and metastasis. The reprogramming of TAMs toward a tumoricidal M1 profile has emerged as an attractive strategy for cancer immunotherapy. In this study, we found that the intratumo...

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Detalles Bibliográficos
Autores principales: Yu, Hua, Bai, Ying, Qiu, Jing, He, Xiaomei, Xiong, Junzhi, Dai, Qian, Wang, Xingmin, Li, Yuanyuan, Sheng, Halei, Xin, Rong, Jiang, Lu, Li, Qiaoqiao, Li, Defeng, Zhang, Hong, Zhang, Le, Chen, Qian, Peng, Jin, Hu, Xiaomei, Zhang, Kebin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654729/
https://www.ncbi.nlm.nih.gov/pubmed/34900687
http://dx.doi.org/10.3389/fonc.2021.736882

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