FDI-6 inhibits the expression and function of FOXM1 to sensitize BRCA-proficient triple-negative breast cancer cells to Olaparib by regulating cell cycle progression and DNA damage repair

Inducing homologous-recombination (HR) deficiency is an effective strategy to broaden the indications of PARP inhibitors in the treatment of triple-negative breast cancer (TNBC). Herein, we find that repression of the oncogenic transcription factor FOXM1 using FOXM1 shRNA or FOXM1 inhibitor FDI-6 ca...

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Detalles Bibliográficos
Autores principales: Wang, Shu-Ping, Wu, Shi-Qi, Huang, Shi-Hui, Tang, Yi-Xuan, Meng, Liu-Qiong, Liu, Feng, Zhu, Qi-Hua, Xu, Yun-Gen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654856/
https://www.ncbi.nlm.nih.gov/pubmed/34880209
http://dx.doi.org/10.1038/s41419-021-04434-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654856/
https://www.ncbi.nlm.nih.gov/pubmed/34880209
http://dx.doi.org/10.1038/s41419-021-04434-9

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