Human miRNA miR-675 inhibits DUX4 expression and may be exploited as a potential treatment for Facioscapulohumeral muscular dystrophy

Facioscapulohumeral muscular dystrophy (FSHD) is a potentially devastating myopathy caused by de-repression of the DUX4 gene in skeletal muscles. Effective therapies will likely involve DUX4 inhibition. RNA interference (RNAi) is one powerful approach to inhibit DUX4, and we previously described a R...

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Detalles Bibliográficos
Autores principales: Saad, Nizar Y., Al-Kharsan, Mustafa, Garwick-Coppens, Sara E., Chermahini, Gholamhossein Amini, Harper, Madison A., Palo, Andrew, Boudreau, Ryan L., Harper, Scott Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654987/
https://www.ncbi.nlm.nih.gov/pubmed/34880230
http://dx.doi.org/10.1038/s41467-021-27430-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8654987/
https://www.ncbi.nlm.nih.gov/pubmed/34880230
http://dx.doi.org/10.1038/s41467-021-27430-1

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