Acetoacetate protects macrophages from lactic acidosis-induced mitochondrial dysfunction by metabolic reprograming

Lactic acidosis, the extracellular accumulation of lactate and protons, is a consequence of increased glycolysis triggered by insufficient oxygen supply to tissues. Macrophages are able to differentiate from monocytes under such acidotic conditions, and remain active in order to resolve the underlyi...

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Detalles Bibliográficos
Autores principales: Adam, Clément, Paolini, Léa, Gueguen, Naïg, Mabilleau, Guillaume, Preisser, Laurence, Blanchard, Simon, Pignon, Pascale, Manero, Florence, Le Mao, Morgane, Morel, Alain, Reynier, Pascal, Beauvillain, Céline, Delneste, Yves, Procaccio, Vincent, Jeannin, Pascale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655019/
https://www.ncbi.nlm.nih.gov/pubmed/34880237
http://dx.doi.org/10.1038/s41467-021-27426-x

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