Modulation of TCR signalling components occurs prior to positive selection and lineage commitment in iNKT cells

iNKT cells play a critical role in controlling the strength and character of adaptive and innate immune responses. Their unique functional characteristics are induced by a transcriptional program initiated by positive selection mediated by CD1d expressed by CD4(+)CD8(+) (double positive, DP) thymocy...

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Detalles Bibliográficos
Autores principales: Dinh, Xuyen T., Stanley, Dragana, Smith, Letitia D., Moreau, Morgane, Berzins, Stuart P., Gemiarto, Adrian, Baxter, Alan G., Jordan, Margaret A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655039/
https://www.ncbi.nlm.nih.gov/pubmed/34880299
http://dx.doi.org/10.1038/s41598-021-02885-w

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