Characterization of a recently synthesized microtubule-targeting compound that disrupts mitotic spindle poles in human cells

We reveal the effects of a new microtubule-destabilizing compound in human cells. C75 has a core thienoisoquinoline scaffold with several functional groups amenable to modification. Previously we found that sub micromolar concentrations of C75 caused cytotoxicity. We also found that C75 inhibited mi...

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Detalles Bibliográficos
Autores principales: Jaunky, Dilan Boodhai, Larocque, Kevin, Husser, Mathieu C., Liu, Jiang Tian, Forgione, Pat, Piekny, Alisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655040/
https://www.ncbi.nlm.nih.gov/pubmed/34880347
http://dx.doi.org/10.1038/s41598-021-03076-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655040/
https://www.ncbi.nlm.nih.gov/pubmed/34880347
http://dx.doi.org/10.1038/s41598-021-03076-3

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