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Characterization of a recently synthesized microtubule-targeting compound that disrupts mitotic spindle poles in human cells
We reveal the effects of a new microtubule-destabilizing compound in human cells. C75 has a core thienoisoquinoline scaffold with several functional groups amenable to modification. Previously we found that sub micromolar concentrations of C75 caused cytotoxicity. We also found that C75 inhibited mi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655040/ https://www.ncbi.nlm.nih.gov/pubmed/34880347 http://dx.doi.org/10.1038/s41598-021-03076-3 |