Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages that carry mutations in the spike gene are of concern for potential impact to treatment and prevention efforts. To monitor for new SARS-CoV-2 mutations, a panel of specimens were sequenced from both wave one (N = ...

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Detalles Bibliográficos
Autores principales: Ahouidi, Ambroise D., Rodgers, Mary A., Padane, Abdou, Leye, Nafissatou, Olivo, Ana, Mbow, Moustapha, Mboup, Aminata, Diaw, Papa Alassane, Dia, Aminata, Harris, Barbara, Padane, Yacine Amet Dia, Lo, Gora, Meyer, Todd V., Diedhiou, Cyrille K., Diagne, Diabou, Kane, Ndeye Coumba Toure, Cloherty, Gavin, Mboup, Souleymane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655062/
https://www.ncbi.nlm.nih.gov/pubmed/34880295
http://dx.doi.org/10.1038/s41598-021-02874-z
Descripción
Sumario:The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages that carry mutations in the spike gene are of concern for potential impact to treatment and prevention efforts. To monitor for new SARS-CoV-2 mutations, a panel of specimens were sequenced from both wave one (N = 96), and wave two (N = 117) of the pandemic in Senegal by whole genome next generation sequencing. Amongst these genomes, new combinations of SARS-CoV-2 spike mutations were identified, with E484K + N501T, L452R + N501Y, and L452M + S477N exclusively found in second wave specimens. These sequences are evidence of local diversification over the course of the pandemic and parallel evolution of escape mutations in different lineages.

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