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Reduced Effectiveness and Comparable Safety in Biweekly vs. Weekly PEGylated Recombinant Human Growth Hormone for Children With Growth Hormone Deficiency: A Phase IV Non-Inferiority Threshold Targeted Trial

CONTEXT: Long-acting recombinant human growth hormone (rhGH) has transformed growth hormone deficiency (GHD) treatment. However, the possibility and rationality for flexible time regimen are pending. OBJECTIVE: We studied the efficacy of biweekly versus weekly PEGylated rhGH (PEG-rhGH) therapy in GH...

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Detalles Bibliográficos
Autores principales:	Sun, Chengjun, Lu, Biao, Liu, Yu, Zhang, Yaqin, Wei, Haiyan, Hu, Xu, Hu, Pei, Zhao, Qian, Liu, Yanling, Ye, Kan, Wang, Kan, Gu, Zaiyan, Liu, Zheng, Ye, Jin, Zhang, Hongxiao, Zhu, Hong, Jiang, Zhihong, Liu, Yanjie, Wan, Naijun, Yan, Chengming, Yin, Jianying, Ying, Lirong, Huang, Feng, Yin, Qingjin, Xi, Li, Luo, Feihong, Cheng, Ruoqian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655095/ https://www.ncbi.nlm.nih.gov/pubmed/34899612 http://dx.doi.org/10.3389/fendo.2021.779365

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