Cargando…
Association Between Low Muscle Mass and Non-alcoholic Fatty Liver Disease Diagnosed Using Ultrasonography, Magnetic Resonance Imaging Derived Proton Density Fat Fraction, and Comprehensive NAFLD Score in Korea
OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent metabolic disease. Muscle is known to influence NAFLD development. Therefore, this study aimed to determine the relationships among low muscle mass, NAFLD, and hepatic fibrosis using various definitions of low muscle...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Preventive Medicine
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655369/ https://www.ncbi.nlm.nih.gov/pubmed/34875824 http://dx.doi.org/10.3961/jpmph.21.387 |
_version_ | 1784612057705873408 |
---|---|
author | Lee, Hun Ju Chang, Jae Seung Ahn, Jhii Hyun Kim, Moon Young Park, Kyu-Sang Ahn, Yeon-Soon Koh, Sang Baek |
author_facet | Lee, Hun Ju Chang, Jae Seung Ahn, Jhii Hyun Kim, Moon Young Park, Kyu-Sang Ahn, Yeon-Soon Koh, Sang Baek |
author_sort | Lee, Hun Ju |
collection | PubMed |
description | OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent metabolic disease. Muscle is known to influence NAFLD development. Therefore, this study aimed to determine the relationships among low muscle mass, NAFLD, and hepatic fibrosis using various definitions of low muscle mass and NAFLD diagnostic methods, including magnetic resonance imaging-based proton density fat fraction (MRI-PDFF). METHODS: This cross-sectional study included 320 participants (107 males, 213 females) from the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population cohort. Muscle mass was assessed using whole-body dual-energy X-ray absorptiometry and adjusted for the height squared, body weight, and body mass index (BMI). NAFLD was diagnosed using ultrasonography (US), MRI-PDFF, and the comprehensive NAFLD score (CNS). Hepatic fibrosis was assessed using magnetic resonance elastography. Multivariable logistic and linear regression analyses were performed to determine the aforementioned associations. RESULTS: According to US, 183 participants (57.2%) had NAFLD. Muscle mass adjusted for body weight was associated with NAFLD diagnosed using US (odds ratio [OR], 3.00; 95% confidence interval [CI], 1.70 to 5.31), MRI-PDFF (OR, 2.00; 95% CI, 1.13 to 3.53), and CNS (OR, 3.39; 95% CI, 1.73 to 6.65) and hepatic fibrosis (males: β=-0.070, p<0.01; females: β=-0.037, p<0.04). Muscle mass adjusted for BMI was associated with NAFLD diagnosed by US (OR, 1.71; 95% CI, 1.02 to 2.86) and CNS (OR, 1.95; 95% CI, 1.04 to 3.65), whereas muscle mass adjusted for height was not associated with NAFLD. CONCLUSIONS: Low muscle mass was associated with NAFLD and liver fibrosis; therefore, maintaining sufficient muscle mass is important to prevent NAFLD. A prospective study and additional consideration of muscle quality are needed to strengthen the findings regarding this association. |
format | Online Article Text |
id | pubmed-8655369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Korean Society for Preventive Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-86553692021-12-22 Association Between Low Muscle Mass and Non-alcoholic Fatty Liver Disease Diagnosed Using Ultrasonography, Magnetic Resonance Imaging Derived Proton Density Fat Fraction, and Comprehensive NAFLD Score in Korea Lee, Hun Ju Chang, Jae Seung Ahn, Jhii Hyun Kim, Moon Young Park, Kyu-Sang Ahn, Yeon-Soon Koh, Sang Baek J Prev Med Public Health Original Article OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent metabolic disease. Muscle is known to influence NAFLD development. Therefore, this study aimed to determine the relationships among low muscle mass, NAFLD, and hepatic fibrosis using various definitions of low muscle mass and NAFLD diagnostic methods, including magnetic resonance imaging-based proton density fat fraction (MRI-PDFF). METHODS: This cross-sectional study included 320 participants (107 males, 213 females) from the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population cohort. Muscle mass was assessed using whole-body dual-energy X-ray absorptiometry and adjusted for the height squared, body weight, and body mass index (BMI). NAFLD was diagnosed using ultrasonography (US), MRI-PDFF, and the comprehensive NAFLD score (CNS). Hepatic fibrosis was assessed using magnetic resonance elastography. Multivariable logistic and linear regression analyses were performed to determine the aforementioned associations. RESULTS: According to US, 183 participants (57.2%) had NAFLD. Muscle mass adjusted for body weight was associated with NAFLD diagnosed using US (odds ratio [OR], 3.00; 95% confidence interval [CI], 1.70 to 5.31), MRI-PDFF (OR, 2.00; 95% CI, 1.13 to 3.53), and CNS (OR, 3.39; 95% CI, 1.73 to 6.65) and hepatic fibrosis (males: β=-0.070, p<0.01; females: β=-0.037, p<0.04). Muscle mass adjusted for BMI was associated with NAFLD diagnosed by US (OR, 1.71; 95% CI, 1.02 to 2.86) and CNS (OR, 1.95; 95% CI, 1.04 to 3.65), whereas muscle mass adjusted for height was not associated with NAFLD. CONCLUSIONS: Low muscle mass was associated with NAFLD and liver fibrosis; therefore, maintaining sufficient muscle mass is important to prevent NAFLD. A prospective study and additional consideration of muscle quality are needed to strengthen the findings regarding this association. Korean Society for Preventive Medicine 2021-11 2021-10-22 /pmc/articles/PMC8655369/ /pubmed/34875824 http://dx.doi.org/10.3961/jpmph.21.387 Text en Copyright © 2021 The Korean Society for Preventive Medicine https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Hun Ju Chang, Jae Seung Ahn, Jhii Hyun Kim, Moon Young Park, Kyu-Sang Ahn, Yeon-Soon Koh, Sang Baek Association Between Low Muscle Mass and Non-alcoholic Fatty Liver Disease Diagnosed Using Ultrasonography, Magnetic Resonance Imaging Derived Proton Density Fat Fraction, and Comprehensive NAFLD Score in Korea |
title | Association Between Low Muscle Mass and Non-alcoholic Fatty Liver Disease Diagnosed Using Ultrasonography, Magnetic Resonance Imaging Derived Proton Density Fat Fraction, and Comprehensive NAFLD Score in Korea |
title_full | Association Between Low Muscle Mass and Non-alcoholic Fatty Liver Disease Diagnosed Using Ultrasonography, Magnetic Resonance Imaging Derived Proton Density Fat Fraction, and Comprehensive NAFLD Score in Korea |
title_fullStr | Association Between Low Muscle Mass and Non-alcoholic Fatty Liver Disease Diagnosed Using Ultrasonography, Magnetic Resonance Imaging Derived Proton Density Fat Fraction, and Comprehensive NAFLD Score in Korea |
title_full_unstemmed | Association Between Low Muscle Mass and Non-alcoholic Fatty Liver Disease Diagnosed Using Ultrasonography, Magnetic Resonance Imaging Derived Proton Density Fat Fraction, and Comprehensive NAFLD Score in Korea |
title_short | Association Between Low Muscle Mass and Non-alcoholic Fatty Liver Disease Diagnosed Using Ultrasonography, Magnetic Resonance Imaging Derived Proton Density Fat Fraction, and Comprehensive NAFLD Score in Korea |
title_sort | association between low muscle mass and non-alcoholic fatty liver disease diagnosed using ultrasonography, magnetic resonance imaging derived proton density fat fraction, and comprehensive nafld score in korea |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655369/ https://www.ncbi.nlm.nih.gov/pubmed/34875824 http://dx.doi.org/10.3961/jpmph.21.387 |
work_keys_str_mv | AT leehunju associationbetweenlowmusclemassandnonalcoholicfattyliverdiseasediagnosedusingultrasonographymagneticresonanceimagingderivedprotondensityfatfractionandcomprehensivenafldscoreinkorea AT changjaeseung associationbetweenlowmusclemassandnonalcoholicfattyliverdiseasediagnosedusingultrasonographymagneticresonanceimagingderivedprotondensityfatfractionandcomprehensivenafldscoreinkorea AT ahnjhiihyun associationbetweenlowmusclemassandnonalcoholicfattyliverdiseasediagnosedusingultrasonographymagneticresonanceimagingderivedprotondensityfatfractionandcomprehensivenafldscoreinkorea AT kimmoonyoung associationbetweenlowmusclemassandnonalcoholicfattyliverdiseasediagnosedusingultrasonographymagneticresonanceimagingderivedprotondensityfatfractionandcomprehensivenafldscoreinkorea AT parkkyusang associationbetweenlowmusclemassandnonalcoholicfattyliverdiseasediagnosedusingultrasonographymagneticresonanceimagingderivedprotondensityfatfractionandcomprehensivenafldscoreinkorea AT ahnyeonsoon associationbetweenlowmusclemassandnonalcoholicfattyliverdiseasediagnosedusingultrasonographymagneticresonanceimagingderivedprotondensityfatfractionandcomprehensivenafldscoreinkorea AT kohsangbaek associationbetweenlowmusclemassandnonalcoholicfattyliverdiseasediagnosedusingultrasonographymagneticresonanceimagingderivedprotondensityfatfractionandcomprehensivenafldscoreinkorea |