The comparison of ZFNs, TALENs, and SpCas9 by GUIDE-seq in HPV-targeted gene therapy

Zinc-finger nucleases (ZFNs), transcription activator-like endonucleases (TALENs), and CRISPR-associated Cas9 endonucleases are three major generations of genome editing tools. However, no parallel comparison about the efficiencies and off-target activity of the three nucleases has been reported, wh...

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Detalles Bibliográficos
Autores principales: Cui, Zifeng, Liu, Hui, Zhang, Hongfeng, Huang, Zhaoyue, Tian, Rui, Li, Lifang, Fan, Weiwen, Chen, Yili, Chen, Lijie, Zhang, Sen, Das, Bhudev C., Severinov, Konstantin, Hitzeroth, Inga Isabel, Debata, Priya Ranjan, Jin, Zhuang, Liu, Jiashuo, Huang, Zheying, Xie, Weiling, Xie, Hongxian, Lang, Bin, Ma, Ji, Weng, Haiyan, Tian, Xun, Hu, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655392/
https://www.ncbi.nlm.nih.gov/pubmed/34938601
http://dx.doi.org/10.1016/j.omtn.2021.08.008

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