Cargando…

Systematic Review of Platelet-Rich Plasma for Rotator Cuff Repair: Are We Adhering to the Minimum Information for Studies Evaluating Biologics in Orthopaedics?

BACKGROUND: The therapeutic efficacy of orthobiologic therapies for rotator cuff repair is difficult to evaluate owing to reporting inconsistences. In response, the Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO) guidelines were developed to ensure standard reporting on o...

Descripción completa

Detalles Bibliográficos
Autores principales: DeClercq, Madeleine G., Fiorentino, Alyson M., Lengel, Haylie A., Ruzbarsky, Joseph J., Robinson, Sara K., Oberlohr, Verena T., Whitney, Kaitlyn E., Millett, Peter J., Huard, Johnny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655472/
https://www.ncbi.nlm.nih.gov/pubmed/34901286
http://dx.doi.org/10.1177/23259671211041971
_version_ 1784612080316317696
author DeClercq, Madeleine G.
Fiorentino, Alyson M.
Lengel, Haylie A.
Ruzbarsky, Joseph J.
Robinson, Sara K.
Oberlohr, Verena T.
Whitney, Kaitlyn E.
Millett, Peter J.
Huard, Johnny
author_facet DeClercq, Madeleine G.
Fiorentino, Alyson M.
Lengel, Haylie A.
Ruzbarsky, Joseph J.
Robinson, Sara K.
Oberlohr, Verena T.
Whitney, Kaitlyn E.
Millett, Peter J.
Huard, Johnny
author_sort DeClercq, Madeleine G.
collection PubMed
description BACKGROUND: The therapeutic efficacy of orthobiologic therapies for rotator cuff repair is difficult to evaluate owing to reporting inconsistences. In response, the Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO) guidelines were developed to ensure standard reporting on orthobiologic therapies. PURPOSE: To systematically review clinical studies evaluating platelet-rich plasma (PRP) for full-thickness rotator cuff repair and adherence to MIBO guidelines. STUDY DESIGN: Scoping review; Level of evidence, 4. METHODS: A search was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines using PubMed, EMBASE, and the Cochrane Library databases. Inclusion criteria were clinical studies reporting on rotator cuff tears (≥1 cm) surgically repaired with PRP. Patient demographics, biologic intervention, and adherence to the MIBO guidelines were systematically reviewed. RESULTS: A total of 19 studies (1005 patients) were included in this review. Across all studies, 58.5% of the MIBO checklist items for PRP were reported. Out of 47 checklist items, 19 were reported in over 85% of studies, whereas 22 were reported in less than half of studies. Details of whole-blood processing and characteristics, as well as PRP processing and characteristics, were reported inconsistently, and no study provided adequate information to enable the precise replication of preparation protocols for PRP. CONCLUSION: This systematic review highlights the current reporting deficiencies within the scientific literature of important variables for evaluating PRP for full-thickness rotator cuff repair. There was widespread variability among published studies that evaluate PRP for this application and, more specifically, studies were limited by inconsistent universal reporting of whole-blood and PRP processing and postprocessing characteristics. To improve our understanding of biologic efficacy and to promote repeatability, stricter adherence to the MIBO guidelines is necessary. We propose that the checklist limitations be addressed and that modification of the MIBO guidelines be considered to improve the reporting of individual components within certain categories.
format Online
Article
Text
id pubmed-8655472
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-86554722021-12-10 Systematic Review of Platelet-Rich Plasma for Rotator Cuff Repair: Are We Adhering to the Minimum Information for Studies Evaluating Biologics in Orthopaedics? DeClercq, Madeleine G. Fiorentino, Alyson M. Lengel, Haylie A. Ruzbarsky, Joseph J. Robinson, Sara K. Oberlohr, Verena T. Whitney, Kaitlyn E. Millett, Peter J. Huard, Johnny Orthop J Sports Med Article BACKGROUND: The therapeutic efficacy of orthobiologic therapies for rotator cuff repair is difficult to evaluate owing to reporting inconsistences. In response, the Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO) guidelines were developed to ensure standard reporting on orthobiologic therapies. PURPOSE: To systematically review clinical studies evaluating platelet-rich plasma (PRP) for full-thickness rotator cuff repair and adherence to MIBO guidelines. STUDY DESIGN: Scoping review; Level of evidence, 4. METHODS: A search was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines using PubMed, EMBASE, and the Cochrane Library databases. Inclusion criteria were clinical studies reporting on rotator cuff tears (≥1 cm) surgically repaired with PRP. Patient demographics, biologic intervention, and adherence to the MIBO guidelines were systematically reviewed. RESULTS: A total of 19 studies (1005 patients) were included in this review. Across all studies, 58.5% of the MIBO checklist items for PRP were reported. Out of 47 checklist items, 19 were reported in over 85% of studies, whereas 22 were reported in less than half of studies. Details of whole-blood processing and characteristics, as well as PRP processing and characteristics, were reported inconsistently, and no study provided adequate information to enable the precise replication of preparation protocols for PRP. CONCLUSION: This systematic review highlights the current reporting deficiencies within the scientific literature of important variables for evaluating PRP for full-thickness rotator cuff repair. There was widespread variability among published studies that evaluate PRP for this application and, more specifically, studies were limited by inconsistent universal reporting of whole-blood and PRP processing and postprocessing characteristics. To improve our understanding of biologic efficacy and to promote repeatability, stricter adherence to the MIBO guidelines is necessary. We propose that the checklist limitations be addressed and that modification of the MIBO guidelines be considered to improve the reporting of individual components within certain categories. SAGE Publications 2021-12-07 /pmc/articles/PMC8655472/ /pubmed/34901286 http://dx.doi.org/10.1177/23259671211041971 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc-nd/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Article
DeClercq, Madeleine G.
Fiorentino, Alyson M.
Lengel, Haylie A.
Ruzbarsky, Joseph J.
Robinson, Sara K.
Oberlohr, Verena T.
Whitney, Kaitlyn E.
Millett, Peter J.
Huard, Johnny
Systematic Review of Platelet-Rich Plasma for Rotator Cuff Repair: Are We Adhering to the Minimum Information for Studies Evaluating Biologics in Orthopaedics?
title Systematic Review of Platelet-Rich Plasma for Rotator Cuff Repair: Are We Adhering to the Minimum Information for Studies Evaluating Biologics in Orthopaedics?
title_full Systematic Review of Platelet-Rich Plasma for Rotator Cuff Repair: Are We Adhering to the Minimum Information for Studies Evaluating Biologics in Orthopaedics?
title_fullStr Systematic Review of Platelet-Rich Plasma for Rotator Cuff Repair: Are We Adhering to the Minimum Information for Studies Evaluating Biologics in Orthopaedics?
title_full_unstemmed Systematic Review of Platelet-Rich Plasma for Rotator Cuff Repair: Are We Adhering to the Minimum Information for Studies Evaluating Biologics in Orthopaedics?
title_short Systematic Review of Platelet-Rich Plasma for Rotator Cuff Repair: Are We Adhering to the Minimum Information for Studies Evaluating Biologics in Orthopaedics?
title_sort systematic review of platelet-rich plasma for rotator cuff repair: are we adhering to the minimum information for studies evaluating biologics in orthopaedics?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655472/
https://www.ncbi.nlm.nih.gov/pubmed/34901286
http://dx.doi.org/10.1177/23259671211041971
work_keys_str_mv AT declercqmadeleineg systematicreviewofplateletrichplasmaforrotatorcuffrepairareweadheringtotheminimuminformationforstudiesevaluatingbiologicsinorthopaedics
AT fiorentinoalysonm systematicreviewofplateletrichplasmaforrotatorcuffrepairareweadheringtotheminimuminformationforstudiesevaluatingbiologicsinorthopaedics
AT lengelhayliea systematicreviewofplateletrichplasmaforrotatorcuffrepairareweadheringtotheminimuminformationforstudiesevaluatingbiologicsinorthopaedics
AT ruzbarskyjosephj systematicreviewofplateletrichplasmaforrotatorcuffrepairareweadheringtotheminimuminformationforstudiesevaluatingbiologicsinorthopaedics
AT robinsonsarak systematicreviewofplateletrichplasmaforrotatorcuffrepairareweadheringtotheminimuminformationforstudiesevaluatingbiologicsinorthopaedics
AT oberlohrverenat systematicreviewofplateletrichplasmaforrotatorcuffrepairareweadheringtotheminimuminformationforstudiesevaluatingbiologicsinorthopaedics
AT whitneykaitlyne systematicreviewofplateletrichplasmaforrotatorcuffrepairareweadheringtotheminimuminformationforstudiesevaluatingbiologicsinorthopaedics
AT millettpeterj systematicreviewofplateletrichplasmaforrotatorcuffrepairareweadheringtotheminimuminformationforstudiesevaluatingbiologicsinorthopaedics
AT huardjohnny systematicreviewofplateletrichplasmaforrotatorcuffrepairareweadheringtotheminimuminformationforstudiesevaluatingbiologicsinorthopaedics