Case Report: Prolonged CSF PCR Positivity in a Neonate With GBS Meningitis

Bacterial meningitis is one of the critical diseases that needs to be diagnosed and treated promptly. Recent diagnostics of high sensitivity and specificity rates, such as PCR, helped with such presentation, especially in cases with prior antibiotics that led to culture negativity. However, the time...

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Autores principales: Alruqaie, Nourah, Falatah, Yara, Alzahrani, Fawaz, Alharbi, Musaed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655720/
https://www.ncbi.nlm.nih.gov/pubmed/34900861
http://dx.doi.org/10.3389/fped.2021.752235
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author Alruqaie, Nourah
Falatah, Yara
Alzahrani, Fawaz
Alharbi, Musaed
author_facet Alruqaie, Nourah
Falatah, Yara
Alzahrani, Fawaz
Alharbi, Musaed
author_sort Alruqaie, Nourah
collection PubMed
description Bacterial meningitis is one of the critical diseases that needs to be diagnosed and treated promptly. Recent diagnostics of high sensitivity and specificity rates, such as PCR, helped with such presentation, especially in cases with prior antibiotics that led to culture negativity. However, the time window of PCR positivity is not well-studied, with scattered reports of different periods of positivity. Here, we report a case of neonatal GBS meningitis with positive PCR for more than 80 days from starting antibiotics.
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spelling pubmed-86557202021-12-10 Case Report: Prolonged CSF PCR Positivity in a Neonate With GBS Meningitis Alruqaie, Nourah Falatah, Yara Alzahrani, Fawaz Alharbi, Musaed Front Pediatr Pediatrics Bacterial meningitis is one of the critical diseases that needs to be diagnosed and treated promptly. Recent diagnostics of high sensitivity and specificity rates, such as PCR, helped with such presentation, especially in cases with prior antibiotics that led to culture negativity. However, the time window of PCR positivity is not well-studied, with scattered reports of different periods of positivity. Here, we report a case of neonatal GBS meningitis with positive PCR for more than 80 days from starting antibiotics. Frontiers Media S.A. 2021-11-25 /pmc/articles/PMC8655720/ /pubmed/34900861 http://dx.doi.org/10.3389/fped.2021.752235 Text en Copyright © 2021 Alruqaie, Falatah, Alzahrani and Alharbi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Alruqaie, Nourah
Falatah, Yara
Alzahrani, Fawaz
Alharbi, Musaed
Case Report: Prolonged CSF PCR Positivity in a Neonate With GBS Meningitis
title Case Report: Prolonged CSF PCR Positivity in a Neonate With GBS Meningitis
title_full Case Report: Prolonged CSF PCR Positivity in a Neonate With GBS Meningitis
title_fullStr Case Report: Prolonged CSF PCR Positivity in a Neonate With GBS Meningitis
title_full_unstemmed Case Report: Prolonged CSF PCR Positivity in a Neonate With GBS Meningitis
title_short Case Report: Prolonged CSF PCR Positivity in a Neonate With GBS Meningitis
title_sort case report: prolonged csf pcr positivity in a neonate with gbs meningitis
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655720/
https://www.ncbi.nlm.nih.gov/pubmed/34900861
http://dx.doi.org/10.3389/fped.2021.752235
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