Extending Native Top-Down Electron Capture Dissociation to MDa Immunoglobulin Complexes Provides Useful Sequence Tags Covering Their Critical Variable Complementarity-Determining Regions

[Image: see text] Native top-down mass spectrometry (MS) is gaining traction for the analysis and sequencing of intact proteins and protein assemblies, giving access to their mass and composition, as well as sequence information useful for identification. Herein, we extend and apply native top-down...

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Detalles Bibliográficos
Autores principales: Greisch, Jean-Francois, den Boer, Maurits A., Lai, Szu-Hsueh, Gallagher, Kelly, Bondt, Albert, Commandeur, Jan, Heck, Albert J.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655740/
https://www.ncbi.nlm.nih.gov/pubmed/34813704
http://dx.doi.org/10.1021/acs.analchem.1c03740

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