Cargando…

Decreases in Dorsal Cervical Spinal Cord White Matter Tract Integrity Are Associated with Elevated Levels of Serum MicroRNA Biomarkers in NCAA Division I Collegiate Football Players

This prospective, controlled, observational cohort study assessed the performance of a novel panel of serum microRNA (miRNA) biomarkers relative to findings on cervical spinal cord magnetic resonance imaging (MRI) in collegiate football players. There were 44 participants included in the study: 30 n...

Descripción completa

Detalles Bibliográficos
Autores principales: Papa, Linda, Johnson, Brian, Walter, Alexa E., Wilkes, James R., Knollmann-Ritschel, Barbara, Bhomia, Manish, Slobounov, Semyon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655801/
https://www.ncbi.nlm.nih.gov/pubmed/34901943
http://dx.doi.org/10.1089/neur.2021.0036
_version_ 1784612147993509888
author Papa, Linda
Johnson, Brian
Walter, Alexa E.
Wilkes, James R.
Knollmann-Ritschel, Barbara
Bhomia, Manish
Slobounov, Semyon M.
author_facet Papa, Linda
Johnson, Brian
Walter, Alexa E.
Wilkes, James R.
Knollmann-Ritschel, Barbara
Bhomia, Manish
Slobounov, Semyon M.
author_sort Papa, Linda
collection PubMed
description This prospective, controlled, observational cohort study assessed the performance of a novel panel of serum microRNA (miRNA) biomarkers relative to findings on cervical spinal cord magnetic resonance imaging (MRI) in collegiate football players. There were 44 participants included in the study: 30 non-athlete control subjects and 14 male collegiate football athletes participating in a Division I Football Bowl Subdivision of the National Collegiate Athletic Association. Diffuse tensor MRI and blood samples were acquired within the week before the athletic season began and within the week after the last game of the season. All miRNAs were significantly higher in athletes regardless of their fractional anisotropy (FA) values (p < 0.001), even those considered to be in the “normal” range of FA for white and gray matter integrity in the cervical spinal cord. miRNA biomarkers were most significantly correlated with FA of the white matter (WM) tracts of the dorsal (posterior) spinal cord; particularly, the fasciculus gracilis, fasciculus cuneatus, lateral corticospinal tract, rubrospinal tract, lateral reticulospinal tract, spinal lemniscus, and spinothalamic and -reticular tracts. Areas under the curve for miRNA biomarkers predicting lower FA of WM dorsal (posterior) cervical spinal tracts, therefore lower white matter integrity (connectivity), were miR-505* = 0.75 (0.54–0.96), miR-30d = 0.74 (0.52–0.95), and miR-92a = 0.75 (0.53–0.98). Should these findings be replicated in a larger cohort of athletes, these markers could potentially serve as measures of neuroimaging abnormalities in athletes at risk for concussion and subconcussive injuries to the cervical spinal cord.
format Online
Article
Text
id pubmed-8655801
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Mary Ann Liebert, Inc., publishers
record_format MEDLINE/PubMed
spelling pubmed-86558012021-12-09 Decreases in Dorsal Cervical Spinal Cord White Matter Tract Integrity Are Associated with Elevated Levels of Serum MicroRNA Biomarkers in NCAA Division I Collegiate Football Players Papa, Linda Johnson, Brian Walter, Alexa E. Wilkes, James R. Knollmann-Ritschel, Barbara Bhomia, Manish Slobounov, Semyon M. Neurotrauma Rep Original Article This prospective, controlled, observational cohort study assessed the performance of a novel panel of serum microRNA (miRNA) biomarkers relative to findings on cervical spinal cord magnetic resonance imaging (MRI) in collegiate football players. There were 44 participants included in the study: 30 non-athlete control subjects and 14 male collegiate football athletes participating in a Division I Football Bowl Subdivision of the National Collegiate Athletic Association. Diffuse tensor MRI and blood samples were acquired within the week before the athletic season began and within the week after the last game of the season. All miRNAs were significantly higher in athletes regardless of their fractional anisotropy (FA) values (p < 0.001), even those considered to be in the “normal” range of FA for white and gray matter integrity in the cervical spinal cord. miRNA biomarkers were most significantly correlated with FA of the white matter (WM) tracts of the dorsal (posterior) spinal cord; particularly, the fasciculus gracilis, fasciculus cuneatus, lateral corticospinal tract, rubrospinal tract, lateral reticulospinal tract, spinal lemniscus, and spinothalamic and -reticular tracts. Areas under the curve for miRNA biomarkers predicting lower FA of WM dorsal (posterior) cervical spinal tracts, therefore lower white matter integrity (connectivity), were miR-505* = 0.75 (0.54–0.96), miR-30d = 0.74 (0.52–0.95), and miR-92a = 0.75 (0.53–0.98). Should these findings be replicated in a larger cohort of athletes, these markers could potentially serve as measures of neuroimaging abnormalities in athletes at risk for concussion and subconcussive injuries to the cervical spinal cord. Mary Ann Liebert, Inc., publishers 2021-10-29 /pmc/articles/PMC8655801/ /pubmed/34901943 http://dx.doi.org/10.1089/neur.2021.0036 Text en © Linda Papa et al., 2021; Published by Mary Ann Liebert, Inc. https://creativecommons.org/licenses/by/4.0/This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Papa, Linda
Johnson, Brian
Walter, Alexa E.
Wilkes, James R.
Knollmann-Ritschel, Barbara
Bhomia, Manish
Slobounov, Semyon M.
Decreases in Dorsal Cervical Spinal Cord White Matter Tract Integrity Are Associated with Elevated Levels of Serum MicroRNA Biomarkers in NCAA Division I Collegiate Football Players
title Decreases in Dorsal Cervical Spinal Cord White Matter Tract Integrity Are Associated with Elevated Levels of Serum MicroRNA Biomarkers in NCAA Division I Collegiate Football Players
title_full Decreases in Dorsal Cervical Spinal Cord White Matter Tract Integrity Are Associated with Elevated Levels of Serum MicroRNA Biomarkers in NCAA Division I Collegiate Football Players
title_fullStr Decreases in Dorsal Cervical Spinal Cord White Matter Tract Integrity Are Associated with Elevated Levels of Serum MicroRNA Biomarkers in NCAA Division I Collegiate Football Players
title_full_unstemmed Decreases in Dorsal Cervical Spinal Cord White Matter Tract Integrity Are Associated with Elevated Levels of Serum MicroRNA Biomarkers in NCAA Division I Collegiate Football Players
title_short Decreases in Dorsal Cervical Spinal Cord White Matter Tract Integrity Are Associated with Elevated Levels of Serum MicroRNA Biomarkers in NCAA Division I Collegiate Football Players
title_sort decreases in dorsal cervical spinal cord white matter tract integrity are associated with elevated levels of serum microrna biomarkers in ncaa division i collegiate football players
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655801/
https://www.ncbi.nlm.nih.gov/pubmed/34901943
http://dx.doi.org/10.1089/neur.2021.0036
work_keys_str_mv AT papalinda decreasesindorsalcervicalspinalcordwhitemattertractintegrityareassociatedwithelevatedlevelsofserummicrornabiomarkersinncaadivisionicollegiatefootballplayers
AT johnsonbrian decreasesindorsalcervicalspinalcordwhitemattertractintegrityareassociatedwithelevatedlevelsofserummicrornabiomarkersinncaadivisionicollegiatefootballplayers
AT walteralexae decreasesindorsalcervicalspinalcordwhitemattertractintegrityareassociatedwithelevatedlevelsofserummicrornabiomarkersinncaadivisionicollegiatefootballplayers
AT wilkesjamesr decreasesindorsalcervicalspinalcordwhitemattertractintegrityareassociatedwithelevatedlevelsofserummicrornabiomarkersinncaadivisionicollegiatefootballplayers
AT knollmannritschelbarbara decreasesindorsalcervicalspinalcordwhitemattertractintegrityareassociatedwithelevatedlevelsofserummicrornabiomarkersinncaadivisionicollegiatefootballplayers
AT bhomiamanish decreasesindorsalcervicalspinalcordwhitemattertractintegrityareassociatedwithelevatedlevelsofserummicrornabiomarkersinncaadivisionicollegiatefootballplayers
AT slobounovsemyonm decreasesindorsalcervicalspinalcordwhitemattertractintegrityareassociatedwithelevatedlevelsofserummicrornabiomarkersinncaadivisionicollegiatefootballplayers