Pyrones Identified as LuxR Signal Molecules in Photorhabdus and Their Synthetic Analogues Can Alter Multicellular Phenotypic Behavior of Bacillus atropheaus

[Image: see text] Individual bacteria communicate by the release and interpretation of small molecules, a phenomenon known as quorum sensing (QS). We hypothesized that QS compounds extruded by Photorhabdus could be interpreted by Bacillus—a form of interspecies communication. We interrogate the stru...

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Autores principales: Hickey, Aobha, Pardo, Leticia M., Reen, F. Jerry, McGlacken, Gerard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655920/
https://www.ncbi.nlm.nih.gov/pubmed/34901665
http://dx.doi.org/10.1021/acsomega.1c05508
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author Hickey, Aobha
Pardo, Leticia M.
Reen, F. Jerry
McGlacken, Gerard P.
author_facet Hickey, Aobha
Pardo, Leticia M.
Reen, F. Jerry
McGlacken, Gerard P.
author_sort Hickey, Aobha
collection PubMed
description [Image: see text] Individual bacteria communicate by the release and interpretation of small molecules, a phenomenon known as quorum sensing (QS). We hypothesized that QS compounds extruded by Photorhabdus could be interpreted by Bacillus—a form of interspecies communication. We interrogate the structure–activity relationship within the recently discovered pyrone QS network and reveal the exquisite structural features required for targeted phenotypic behavior. The interruption of QS is an exciting, nonbiocidal approach to tackling infection, and understanding its nuances can only be achieved by studies such as this.
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spelling pubmed-86559202021-12-10 Pyrones Identified as LuxR Signal Molecules in Photorhabdus and Their Synthetic Analogues Can Alter Multicellular Phenotypic Behavior of Bacillus atropheaus Hickey, Aobha Pardo, Leticia M. Reen, F. Jerry McGlacken, Gerard P. ACS Omega [Image: see text] Individual bacteria communicate by the release and interpretation of small molecules, a phenomenon known as quorum sensing (QS). We hypothesized that QS compounds extruded by Photorhabdus could be interpreted by Bacillus—a form of interspecies communication. We interrogate the structure–activity relationship within the recently discovered pyrone QS network and reveal the exquisite structural features required for targeted phenotypic behavior. The interruption of QS is an exciting, nonbiocidal approach to tackling infection, and understanding its nuances can only be achieved by studies such as this. American Chemical Society 2021-11-22 /pmc/articles/PMC8655920/ /pubmed/34901665 http://dx.doi.org/10.1021/acsomega.1c05508 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Hickey, Aobha
Pardo, Leticia M.
Reen, F. Jerry
McGlacken, Gerard P.
Pyrones Identified as LuxR Signal Molecules in Photorhabdus and Their Synthetic Analogues Can Alter Multicellular Phenotypic Behavior of Bacillus atropheaus
title Pyrones Identified as LuxR Signal Molecules in Photorhabdus and Their Synthetic Analogues Can Alter Multicellular Phenotypic Behavior of Bacillus atropheaus
title_full Pyrones Identified as LuxR Signal Molecules in Photorhabdus and Their Synthetic Analogues Can Alter Multicellular Phenotypic Behavior of Bacillus atropheaus
title_fullStr Pyrones Identified as LuxR Signal Molecules in Photorhabdus and Their Synthetic Analogues Can Alter Multicellular Phenotypic Behavior of Bacillus atropheaus
title_full_unstemmed Pyrones Identified as LuxR Signal Molecules in Photorhabdus and Their Synthetic Analogues Can Alter Multicellular Phenotypic Behavior of Bacillus atropheaus
title_short Pyrones Identified as LuxR Signal Molecules in Photorhabdus and Their Synthetic Analogues Can Alter Multicellular Phenotypic Behavior of Bacillus atropheaus
title_sort pyrones identified as luxr signal molecules in photorhabdus and their synthetic analogues can alter multicellular phenotypic behavior of bacillus atropheaus
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655920/
https://www.ncbi.nlm.nih.gov/pubmed/34901665
http://dx.doi.org/10.1021/acsomega.1c05508
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