Spotlight on Isl1: A Key Player in Cardiovascular Development and Diseases

Cardiac transcription factors orchestrate a regulatory network controlling cardiovascular development. Isl1, a LIM-homeodomain transcription factor, acts as a key player in multiple organs during embryonic development. Its crucial roles in cardiovascular development have been elucidated by extensive...

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Detalles Bibliográficos
Autores principales: Ren, Jie, Miao, Danxiu, Li, Yanshu, Gao, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656156/
https://www.ncbi.nlm.nih.gov/pubmed/34901033
http://dx.doi.org/10.3389/fcell.2021.793605
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author Ren, Jie
Miao, Danxiu
Li, Yanshu
Gao, Rui
author_facet Ren, Jie
Miao, Danxiu
Li, Yanshu
Gao, Rui
author_sort Ren, Jie
collection PubMed
description Cardiac transcription factors orchestrate a regulatory network controlling cardiovascular development. Isl1, a LIM-homeodomain transcription factor, acts as a key player in multiple organs during embryonic development. Its crucial roles in cardiovascular development have been elucidated by extensive studies, especially as a marker gene for the second heart field progenitors. Here, we summarize the roles of Isl1 in cardiovascular development and function, and outline its cellular and molecular modes of action, thus providing insights for the molecular basis of cardiovascular diseases.
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spelling pubmed-86561562021-12-10 Spotlight on Isl1: A Key Player in Cardiovascular Development and Diseases Ren, Jie Miao, Danxiu Li, Yanshu Gao, Rui Front Cell Dev Biol Cell and Developmental Biology Cardiac transcription factors orchestrate a regulatory network controlling cardiovascular development. Isl1, a LIM-homeodomain transcription factor, acts as a key player in multiple organs during embryonic development. Its crucial roles in cardiovascular development have been elucidated by extensive studies, especially as a marker gene for the second heart field progenitors. Here, we summarize the roles of Isl1 in cardiovascular development and function, and outline its cellular and molecular modes of action, thus providing insights for the molecular basis of cardiovascular diseases. Frontiers Media S.A. 2021-11-25 /pmc/articles/PMC8656156/ /pubmed/34901033 http://dx.doi.org/10.3389/fcell.2021.793605 Text en Copyright © 2021 Ren, Miao, Li and Gao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Ren, Jie
Miao, Danxiu
Li, Yanshu
Gao, Rui
Spotlight on Isl1: A Key Player in Cardiovascular Development and Diseases
title Spotlight on Isl1: A Key Player in Cardiovascular Development and Diseases
title_full Spotlight on Isl1: A Key Player in Cardiovascular Development and Diseases
title_fullStr Spotlight on Isl1: A Key Player in Cardiovascular Development and Diseases
title_full_unstemmed Spotlight on Isl1: A Key Player in Cardiovascular Development and Diseases
title_short Spotlight on Isl1: A Key Player in Cardiovascular Development and Diseases
title_sort spotlight on isl1: a key player in cardiovascular development and diseases
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656156/
https://www.ncbi.nlm.nih.gov/pubmed/34901033
http://dx.doi.org/10.3389/fcell.2021.793605
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AT liyanshu spotlightonisl1akeyplayerincardiovasculardevelopmentanddiseases
AT gaorui spotlightonisl1akeyplayerincardiovasculardevelopmentanddiseases

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