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Characterization of Alpelisib in Rat Plasma by a Newly Developed UPLC-MS/MS Method: Application to a Drug-Drug Interaction Study

Alpelisib, an oral selective and small-molecule phosphoinositide 3-kinase inhibitor, was lately approved in the United States to treat breast cancer. A sensitive method to quantify alpelisib levels in rat plasma on the basis of ultra-performance liquid chromatography–tandem mass spectrometry techniq...

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Detalles Bibliográficos
Autores principales:	Wang, Qiong, Lan, Xia, Zhao, Zhuofei, Su, Xiaohang, Zhang, Yuji, Zhou, Xiao-Yang, Xu, Ren-Ai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656162/ https://www.ncbi.nlm.nih.gov/pubmed/34899297 http://dx.doi.org/10.3389/fphar.2021.743411

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