Cargando…

Untargeted and Targeted Metabolomics Reveal the Underlying Mechanism of Aspirin Eugenol Ester Ameliorating Rat Hyperlipidemia via Inhibiting FXR to Induce CYP7A1

Hyperlipidemia is an important lipid disorder and a risk factor for health. Aspirin eugenol ester (AEE) is a novel synthetic compound which is made up of two chemical structural units from aspirin and eugenol. Therapeutic effect of AEE on hyperlipidemia has been confirmed in animal model. But the ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao-Rong, Lu, Ning, Ma, Xi-Wang, Liu, Shi-Hong, Li, Zhe, Qin, Li-Xia, Bai, Ya-Jun, Yang, Jian-Yong, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656224/ https://www.ncbi.nlm.nih.gov/pubmed/34899293 http://dx.doi.org/10.3389/fphar.2021.733789

Ejemplares similares

Untargeted lipidomics and metagenomics reveal the mechanism of aspirin eugenol ester relieving hyperlipidemia in ApoE−/− mice
por: Lu, Xiao-Rong, et al.
Publicado: (2022)

Aspirin eugenol ester regulates cecal contents metabolomic profile and microbiota in an animal model of hyperlipidemia
por: Ma, Ning, et al.
Publicado: (2018)

Investigation of the Uptake and Transport of Aspirin Eugenol Ester in the Caco-2 Cell Model
por: Tao, Qi, et al.
Publicado: (2022)

Regulation effect of Aspirin Eugenol Ester on blood lipids in Wistar rats with hyperlipidemia
por: Karam, Isam, et al.
Publicado: (2015)

Aspirin eugenol ester ameliorates LPS-induced inflammatory responses in RAW264.7 cells and mice
por: Liu, Xu, et al.
Publicado: (2023)

Aspirin Eugenol Ester Protects Vascular Endothelium From Oxidative Injury by the Apoptosis Signal Regulating Kinase-1 Pathway
por: Huang, Mei-Zhou, et al.
Publicado: (2020)

Cellular Metabolomics Reveal the Mechanism Underlying the Anti-Atherosclerotic Effects of Aspirin Eugenol Ester on Vascular Endothelial Dysfunction
por: Huang, Mei-Zhou, et al.
Publicado: (2019)

Aspirin Eugenol Ester Attenuates Paraquat-Induced Hepatotoxicity by Inhibiting Oxidative Stress
por: Zhang, Zhen-Dong, et al.
Publicado: (2020)

The Protective Effect of Aspirin Eugenol Ester on Paraquat-Induced Acute Liver Injury Rats
por: Zhang, Zhen-Dong, et al.
Publicado: (2020)

UPLC-Q-TOF/MS-Based Plasma Metabolomics to Evaluate the Effects of Aspirin Eugenol Ester on Blood Stasis in Rats
por: Shen, Dongshuai, et al.
Publicado: (2019)

Protective Activity of Aspirin Eugenol Ester on Paraquat-Induced Cell Damage in SH-SY5Y Cells
por: Zhang, Zhen-Dong, et al.
Publicado: (2021)

Lowering effects of aspirin eugenol ester on blood lipids in rats with high fat diet
por: Karam, Isam, et al.
Publicado: (2016)

Aspirin eugenol ester alleviates lipopolysaccharide-induced acute lung injury in rats while stabilizing serum metabolites levels
por: Tao, Qi, et al.
Publicado: (2022)

Preventive Effect of Aspirin Eugenol Ester on Thrombosis in κ-Carrageenan-Induced Rat Tail Thrombosis Model
por: Ma, Ning, et al.
Publicado: (2015)

Wuwei Qingzhuo San Ameliorates Hyperlipidemia in Mice Fed With HFD by Regulating Metabolomics and Intestinal Flora Composition
por: Ge, Shasha, et al.
Publicado: (2022)

Aspirin Eugenol Ester Reduces H(2)O(2)-Induced Oxidative Stress of HUVECs via Mitochondria-Lysosome Axis
por: Huang, Mei-Zhou, et al.
Publicado: (2019)

UPLC-Q-TOF/MS-based metabonomic studies on the intervention effects of aspirin eugenol ester in atherosclerosis hamsters
por: Ma, Ning, et al.
Publicado: (2017)

Impact of Aspirin Eugenol Ester on Cyclooxygenase-1, Cyclooxygenase-2, C-Reactive Protein, Prothrombin and Arachidonate 5-Lipoxygenase in Healthy Rats
por: Ma, Ning, et al.
Publicado: (2017)

The Protective Effect of Aspirin Eugenol Ester on Oxidative Stress to PC12 Cells Stimulated with H(2)O(2) through Regulating PI3K/Akt Signal Pathway
por: Zhang, Zhen-Dong, et al.
Publicado: (2021)

Diammonium Glycyrrhizinate Ameliorates Obesity Through Modulation of Gut Microbiota-Conjugated BAs-FXR Signaling
por: Li, Yun, et al.
Publicado: (2021)

Metabolomic and lipidomic studies on the intervention of taurochenodeoxycholic acid in mice with hyperlipidemia
por: Cui, Na, et al.
Publicado: (2023)

Alterations in the gut microbiota and serum metabolomics of spontaneous cholestasis caused by loss of FXR signal in mice
por: Wei, Shizhang, et al.
Publicado: (2023)

Untargeted Metabolomics Reveals Dose-Response Characteristics for Effect of Rhubarb in a Rat Model of Cholestasis
por: Zhang, Cong-En, et al.
Publicado: (2016)

Integrating Targeted and Untargeted Metabolomics to Investigate the Processing Chemistry of Polygoni Multiflori Radix
por: Liang, Li, et al.
Publicado: (2018)

Evaluation of Untargeted Metabolomic Strategy for the Discovery of Biomarker of Breast Cancer
por: Ruan, Xujun, et al.
Publicado: (2022)

Evaluation on antithrombotic effect of aspirin eugenol ester from the view of platelet aggregation, hemorheology, TXB(2)/6-keto-PGF(1α) and blood biochemistry in rat model
por: Ma, Ning, et al.
Publicado: (2016)

Feces and liver tissue metabonomics studies on the regulatory effect of aspirin eugenol eater in hyperlipidemic rats
por: Ma, Ning, et al.
Publicado: (2017)

Metabolic Insight Into the Neuroprotective Effect of Tao-He-Cheng-Qi (THCQ) Decoction on ICH Rats Using Untargeted Metabolomics
por: Yang, Rui-Pei, et al.
Publicado: (2021)

Allium victorialis L. Extracts Promote Activity of FXR to Ameliorate Alcoholic Liver Disease: Targeting Liver Lipid Deposition and Inflammation
por: Cui, Zhen-Yu, et al.
Publicado: (2021)

Epimedium koreanum Nakai–Induced Liver Injury—A Mechanistic Study Using Untargeted Metabolomics
por: Li, Pin, et al.
Publicado: (2022)

Untargeted Metabolomic Analysis of the Effects and Mechanism of Nuciferine Treatment on Rats With Nonalcoholic Fatty Liver Disease
por: Cui, Huantian, et al.
Publicado: (2020)

Metabolomic Analysis of Platelets of Patients With Aspirin Non-Response
por: Chiang, Jiun-Yang, et al.
Publicado: (2019)

Metabolomics analysis delineates the therapeutic effects of Yinlan Tiaozhi capsule on triton WR-1339 -induced hyperlipidemia in mice
por: Xiao, Guanlin, et al.
Publicado: (2023)

Untargeted Metabolomics Reveals the Protective Effect of Fufang Zhenshu Tiaozhi (FTZ) on Aging-Induced Osteoporosis in Mice
por: Luo, Duosheng, et al.
Publicado: (2019)

Obeticholic Acid Induces Hepatoxicity Via FXR in the NAFLD Mice
por: Lin, Chuangzhen, et al.
Publicado: (2022)

Potential cardiotoxicity induced by Euodiae Fructus: In vivo and in vitro experiments and untargeted metabolomics research
por: Zhang, Dan, et al.
Publicado: (2022)

Using an untargeted metabolomics approach to analyze serum metabolites in COVID-19 patients with nucleic acid turning negative
por: Chen, Wenyu, et al.
Publicado: (2022)

Protective effects of Descurainia sophia seeds extract and its fractions on pulmonary edema by untargeted urine and serum metabolomics strategy
por: Zhang, Jinying, et al.
Publicado: (2023)

Regulation of X-Ray Irradiation on the Activity and Expression Levels of CYP1A2 and CYP2E1 in Rats
por: Li, Xiang-Yang, et al.
Publicado: (2020)

Untargeted and Targeted Metabolomics Reveal the Active Peptide of Eupolyphaga sinensis Walker against Hyperlipidemia by Modulating Imbalance in Amino Acid Metabolism
por: Li, Yanan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_bfh5o5lebovkgvdvv2potvlqlf