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Targeting Tumor-Stromal Interactions in Pancreatic Cancer: Impact of Collagens and Mechanical Traits

Pancreatic ductal adenocarcinoma (PDAC) has one of the worst outcomes among cancers with a 5-years survival rate of below 10%. This is a result of late diagnosis and the lack of effective treatments. The tumor is characterized by a highly fibrotic stroma containing distinct cellular components, embe...

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Detalles Bibliográficos
Autores principales: Maneshi, Parniyan, Mason, James, Dongre, Mitesh, Öhlund, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656238/
https://www.ncbi.nlm.nih.gov/pubmed/34901028
http://dx.doi.org/10.3389/fcell.2021.787485