Cargando…

Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective

Severe bone injuries can result in disabilities and thus affect a person's quality of life. Mesenchymal stem cells (MSCs) can be an alternative for bone healing by growing them on nanopatterned substrates that provide mechanical signals for differentiation. This review aims to highlight the rol...

Descripción completa

Detalles Bibliográficos
Autores principales: Barlian, Anggraini, Vanya, Katherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656311/
https://www.ncbi.nlm.nih.gov/pubmed/34900339
http://dx.doi.org/10.2144/fsoa-2021-0097
_version_ 1784612257521467392
author Barlian, Anggraini
Vanya, Katherine
author_facet Barlian, Anggraini
Vanya, Katherine
author_sort Barlian, Anggraini
collection PubMed
description Severe bone injuries can result in disabilities and thus affect a person's quality of life. Mesenchymal stem cells (MSCs) can be an alternative for bone healing by growing them on nanopatterned substrates that provide mechanical signals for differentiation. This review aims to highlight the role of nanopatterns in directing or inducing MSC osteogenic differentiation, especially in bone tissue engineering. Nanopatterns can upregulate the expression of osteogenic markers, which indicates a faster differentiation process. Combined with growth factors, nanopatterns can further upregulate osteogenic markers, but with fewer growth factors needed, thereby reducing the risks and costs involved. Nanopatterns can be applied in scaffolds for tissue engineering for their lasting effects, even in vivo, thus having great potential for future bone treatment.
format Online
Article
Text
id pubmed-8656311
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Future Science Ltd
record_format MEDLINE/PubMed
spelling pubmed-86563112021-12-10 Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective Barlian, Anggraini Vanya, Katherine Future Sci OA Review Severe bone injuries can result in disabilities and thus affect a person's quality of life. Mesenchymal stem cells (MSCs) can be an alternative for bone healing by growing them on nanopatterned substrates that provide mechanical signals for differentiation. This review aims to highlight the role of nanopatterns in directing or inducing MSC osteogenic differentiation, especially in bone tissue engineering. Nanopatterns can upregulate the expression of osteogenic markers, which indicates a faster differentiation process. Combined with growth factors, nanopatterns can further upregulate osteogenic markers, but with fewer growth factors needed, thereby reducing the risks and costs involved. Nanopatterns can be applied in scaffolds for tissue engineering for their lasting effects, even in vivo, thus having great potential for future bone treatment. Future Science Ltd 2021-11-18 /pmc/articles/PMC8656311/ /pubmed/34900339 http://dx.doi.org/10.2144/fsoa-2021-0097 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Review
Barlian, Anggraini
Vanya, Katherine
Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective
title Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective
title_full Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective
title_fullStr Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective
title_full_unstemmed Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective
title_short Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective
title_sort nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656311/
https://www.ncbi.nlm.nih.gov/pubmed/34900339
http://dx.doi.org/10.2144/fsoa-2021-0097
work_keys_str_mv AT barliananggraini nanotopographyindirectingosteogenicdifferentiationofmesenchymalstemcellspotencyandfutureperspective
AT vanyakatherine nanotopographyindirectingosteogenicdifferentiationofmesenchymalstemcellspotencyandfutureperspective