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Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective
Severe bone injuries can result in disabilities and thus affect a person's quality of life. Mesenchymal stem cells (MSCs) can be an alternative for bone healing by growing them on nanopatterned substrates that provide mechanical signals for differentiation. This review aims to highlight the rol...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Science Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656311/ https://www.ncbi.nlm.nih.gov/pubmed/34900339 http://dx.doi.org/10.2144/fsoa-2021-0097 |
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author | Barlian, Anggraini Vanya, Katherine |
author_facet | Barlian, Anggraini Vanya, Katherine |
author_sort | Barlian, Anggraini |
collection | PubMed |
description | Severe bone injuries can result in disabilities and thus affect a person's quality of life. Mesenchymal stem cells (MSCs) can be an alternative for bone healing by growing them on nanopatterned substrates that provide mechanical signals for differentiation. This review aims to highlight the role of nanopatterns in directing or inducing MSC osteogenic differentiation, especially in bone tissue engineering. Nanopatterns can upregulate the expression of osteogenic markers, which indicates a faster differentiation process. Combined with growth factors, nanopatterns can further upregulate osteogenic markers, but with fewer growth factors needed, thereby reducing the risks and costs involved. Nanopatterns can be applied in scaffolds for tissue engineering for their lasting effects, even in vivo, thus having great potential for future bone treatment. |
format | Online Article Text |
id | pubmed-8656311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Future Science Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-86563112021-12-10 Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective Barlian, Anggraini Vanya, Katherine Future Sci OA Review Severe bone injuries can result in disabilities and thus affect a person's quality of life. Mesenchymal stem cells (MSCs) can be an alternative for bone healing by growing them on nanopatterned substrates that provide mechanical signals for differentiation. This review aims to highlight the role of nanopatterns in directing or inducing MSC osteogenic differentiation, especially in bone tissue engineering. Nanopatterns can upregulate the expression of osteogenic markers, which indicates a faster differentiation process. Combined with growth factors, nanopatterns can further upregulate osteogenic markers, but with fewer growth factors needed, thereby reducing the risks and costs involved. Nanopatterns can be applied in scaffolds for tissue engineering for their lasting effects, even in vivo, thus having great potential for future bone treatment. Future Science Ltd 2021-11-18 /pmc/articles/PMC8656311/ /pubmed/34900339 http://dx.doi.org/10.2144/fsoa-2021-0097 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Review Barlian, Anggraini Vanya, Katherine Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective |
title | Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective |
title_full | Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective |
title_fullStr | Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective |
title_full_unstemmed | Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective |
title_short | Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective |
title_sort | nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656311/ https://www.ncbi.nlm.nih.gov/pubmed/34900339 http://dx.doi.org/10.2144/fsoa-2021-0097 |
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