Analysis of somatic copy number alterations in biliary tract carcinoma using a single nucleotide polymorphism array

AIM: Biliary tract carcinoma (BTC), including gall bladder carcinoma (GBC) and biliary duct carcinoma (BDC), has a poor prognosis. Comprehensive genomic profiling has important roles in evaluation of the carcinogenesis of BTC. MATERIALS & METHODS: We examined somatic copy number alterations (SCN...

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Autores principales: Shioi, Yoshihiro, Osakabe, Mitsumasa, Yanagawa, Naoki, Nitta, Hiroyuki, Sasaki, Akira, Sugai, Tamotsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656348/
https://www.ncbi.nlm.nih.gov/pubmed/34900340
http://dx.doi.org/10.2144/fsoa-2021-0057
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author Shioi, Yoshihiro
Osakabe, Mitsumasa
Yanagawa, Naoki
Nitta, Hiroyuki
Sasaki, Akira
Sugai, Tamotsu
author_facet Shioi, Yoshihiro
Osakabe, Mitsumasa
Yanagawa, Naoki
Nitta, Hiroyuki
Sasaki, Akira
Sugai, Tamotsu
author_sort Shioi, Yoshihiro
collection PubMed
description AIM: Biliary tract carcinoma (BTC), including gall bladder carcinoma (GBC) and biliary duct carcinoma (BDC), has a poor prognosis. Comprehensive genomic profiling has important roles in evaluation of the carcinogenesis of BTC. MATERIALS & METHODS: We examined somatic copy number alterations (SCNAs) using a single nucleotide polymorphism array system to analyze 36 BTC samples (11 GBCs and 25 BDCs). RESULTS: In hierarchical cluster analysis, two clusters were identified (subgroup 1 with low SCNAs and subgroup 2 with high SCNAs). GBC was predominant in subgroup 1, whereas BDC was predominant in subgroup 2, suggesting that GBC and BDC had different genetic backgrounds in terms of SCNAs. CONCLUSION: These findings could be helpful for establishing the molecular carcinogenesis of BTCs.
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spelling pubmed-86563482021-12-10 Analysis of somatic copy number alterations in biliary tract carcinoma using a single nucleotide polymorphism array Shioi, Yoshihiro Osakabe, Mitsumasa Yanagawa, Naoki Nitta, Hiroyuki Sasaki, Akira Sugai, Tamotsu Future Sci OA Research Article AIM: Biliary tract carcinoma (BTC), including gall bladder carcinoma (GBC) and biliary duct carcinoma (BDC), has a poor prognosis. Comprehensive genomic profiling has important roles in evaluation of the carcinogenesis of BTC. MATERIALS & METHODS: We examined somatic copy number alterations (SCNAs) using a single nucleotide polymorphism array system to analyze 36 BTC samples (11 GBCs and 25 BDCs). RESULTS: In hierarchical cluster analysis, two clusters were identified (subgroup 1 with low SCNAs and subgroup 2 with high SCNAs). GBC was predominant in subgroup 1, whereas BDC was predominant in subgroup 2, suggesting that GBC and BDC had different genetic backgrounds in terms of SCNAs. CONCLUSION: These findings could be helpful for establishing the molecular carcinogenesis of BTCs. Future Science Ltd 2021-11-15 /pmc/articles/PMC8656348/ /pubmed/34900340 http://dx.doi.org/10.2144/fsoa-2021-0057 Text en © 2021 Tamotsu Sugai https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Research Article
Shioi, Yoshihiro
Osakabe, Mitsumasa
Yanagawa, Naoki
Nitta, Hiroyuki
Sasaki, Akira
Sugai, Tamotsu
Analysis of somatic copy number alterations in biliary tract carcinoma using a single nucleotide polymorphism array
title Analysis of somatic copy number alterations in biliary tract carcinoma using a single nucleotide polymorphism array
title_full Analysis of somatic copy number alterations in biliary tract carcinoma using a single nucleotide polymorphism array
title_fullStr Analysis of somatic copy number alterations in biliary tract carcinoma using a single nucleotide polymorphism array
title_full_unstemmed Analysis of somatic copy number alterations in biliary tract carcinoma using a single nucleotide polymorphism array
title_short Analysis of somatic copy number alterations in biliary tract carcinoma using a single nucleotide polymorphism array
title_sort analysis of somatic copy number alterations in biliary tract carcinoma using a single nucleotide polymorphism array
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656348/
https://www.ncbi.nlm.nih.gov/pubmed/34900340
http://dx.doi.org/10.2144/fsoa-2021-0057
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