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Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle

The septin family of proteins can assemble into filaments that further organize into different higher order structures to perform a variety of different functions in different cell types and organisms. In the budding yeast Saccharomyces cerevisiae, the septins localize to the presumptive bud site as...

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Autores principales: Marquardt, Joseph, Chen, Xi, Bi, Erfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656427/
https://www.ncbi.nlm.nih.gov/pubmed/34901034
http://dx.doi.org/10.3389/fcell.2021.793920
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author Marquardt, Joseph
Chen, Xi
Bi, Erfei
author_facet Marquardt, Joseph
Chen, Xi
Bi, Erfei
author_sort Marquardt, Joseph
collection PubMed
description The septin family of proteins can assemble into filaments that further organize into different higher order structures to perform a variety of different functions in different cell types and organisms. In the budding yeast Saccharomyces cerevisiae, the septins localize to the presumptive bud site as a cortical ring prior to bud emergence, expand into an hourglass at the bud neck (cell division site) during bud growth, and finally “split” into a double ring sandwiching the cell division machinery during cytokinesis. While much work has been done to understand the functions and molecular makeups of these structures, the mechanisms underlying the transitions from one structure to another have largely remained elusive. Recent studies involving advanced imaging and in vitro reconstitution have begun to reveal the vast complexity involved in the regulation of these structural transitions, which defines the focus of discussion in this mini-review.
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spelling pubmed-86564272021-12-10 Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle Marquardt, Joseph Chen, Xi Bi, Erfei Front Cell Dev Biol Cell and Developmental Biology The septin family of proteins can assemble into filaments that further organize into different higher order structures to perform a variety of different functions in different cell types and organisms. In the budding yeast Saccharomyces cerevisiae, the septins localize to the presumptive bud site as a cortical ring prior to bud emergence, expand into an hourglass at the bud neck (cell division site) during bud growth, and finally “split” into a double ring sandwiching the cell division machinery during cytokinesis. While much work has been done to understand the functions and molecular makeups of these structures, the mechanisms underlying the transitions from one structure to another have largely remained elusive. Recent studies involving advanced imaging and in vitro reconstitution have begun to reveal the vast complexity involved in the regulation of these structural transitions, which defines the focus of discussion in this mini-review. Frontiers Media S.A. 2021-11-25 /pmc/articles/PMC8656427/ /pubmed/34901034 http://dx.doi.org/10.3389/fcell.2021.793920 Text en Copyright © 2021 Marquardt, Chen and Bi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Marquardt, Joseph
Chen, Xi
Bi, Erfei
Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle
title Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle
title_full Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle
title_fullStr Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle
title_full_unstemmed Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle
title_short Septin Assembly and Remodeling at the Cell Division Site During the Cell Cycle
title_sort septin assembly and remodeling at the cell division site during the cell cycle
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656427/
https://www.ncbi.nlm.nih.gov/pubmed/34901034
http://dx.doi.org/10.3389/fcell.2021.793920
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