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The Role of Innate Immune Cells in Tumor Invasion and Metastasis

SIMPLE SUMMARY: Tumor invasion and metastasis are one of the main reasons patients succumb to cancer. In this review, we summarize recent studies which provide evidence on the involvement of cells of the innate immune system and their function in invasion and metastasis. ABSTRACT: Metastasis is cons...

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Autores principales: Huang, Yu-Kuan, Busuttil, Rita A., Boussioutas, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656477/
https://www.ncbi.nlm.nih.gov/pubmed/34884995
http://dx.doi.org/10.3390/cancers13235885
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author Huang, Yu-Kuan
Busuttil, Rita A.
Boussioutas, Alex
author_facet Huang, Yu-Kuan
Busuttil, Rita A.
Boussioutas, Alex
author_sort Huang, Yu-Kuan
collection PubMed
description SIMPLE SUMMARY: Tumor invasion and metastasis are one of the main reasons patients succumb to cancer. In this review, we summarize recent studies which provide evidence on the involvement of cells of the innate immune system and their function in invasion and metastasis. ABSTRACT: Metastasis is considered one of the hallmarks of cancer and enhanced tumor invasion and metastasis is significantly associated with cancer mortality. Metastasis occurs via a series of integrated processes involving tumor cells and the tumor microenvironment. The innate immune components of the microenvironment have been shown to engage with tumor cells and not only regulate their proliferation and survival, but also modulate the surrounding environment to enable cancer progression. In the era of immune therapies, it is critical to understand how different innate immune cell populations are involved in this process. This review summarizes recent literature describing the roles of innate immune cells during the tumor metastatic cascade.
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spelling pubmed-86564772021-12-10 The Role of Innate Immune Cells in Tumor Invasion and Metastasis Huang, Yu-Kuan Busuttil, Rita A. Boussioutas, Alex Cancers (Basel) Review SIMPLE SUMMARY: Tumor invasion and metastasis are one of the main reasons patients succumb to cancer. In this review, we summarize recent studies which provide evidence on the involvement of cells of the innate immune system and their function in invasion and metastasis. ABSTRACT: Metastasis is considered one of the hallmarks of cancer and enhanced tumor invasion and metastasis is significantly associated with cancer mortality. Metastasis occurs via a series of integrated processes involving tumor cells and the tumor microenvironment. The innate immune components of the microenvironment have been shown to engage with tumor cells and not only regulate their proliferation and survival, but also modulate the surrounding environment to enable cancer progression. In the era of immune therapies, it is critical to understand how different innate immune cell populations are involved in this process. This review summarizes recent literature describing the roles of innate immune cells during the tumor metastatic cascade. MDPI 2021-11-23 /pmc/articles/PMC8656477/ /pubmed/34884995 http://dx.doi.org/10.3390/cancers13235885 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Huang, Yu-Kuan
Busuttil, Rita A.
Boussioutas, Alex
The Role of Innate Immune Cells in Tumor Invasion and Metastasis
title The Role of Innate Immune Cells in Tumor Invasion and Metastasis
title_full The Role of Innate Immune Cells in Tumor Invasion and Metastasis
title_fullStr The Role of Innate Immune Cells in Tumor Invasion and Metastasis
title_full_unstemmed The Role of Innate Immune Cells in Tumor Invasion and Metastasis
title_short The Role of Innate Immune Cells in Tumor Invasion and Metastasis
title_sort role of innate immune cells in tumor invasion and metastasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656477/
https://www.ncbi.nlm.nih.gov/pubmed/34884995
http://dx.doi.org/10.3390/cancers13235885
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