AMP-Activated Protein Kinase Contributes to Apoptosis Induced by the Bcl-2 Inhibitor Venetoclax in Acute Myeloid Leukemia

SIMPLE SUMMARY: The Bcl2 inhibitor venetoclax is a breakthrough therapy in acute myeloid leukemia (AML). We show that venetoclax induces caspase-dependent degradation of AMPK, a central regulator of cellular energy metabolism, with implications in the anti-Leukemic activity of venetoclax in AML. ABS...

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Detalles Bibliográficos
Autores principales: Legrand, Noémie, Pradier, Amandine, Poulain, Laury, Mouche, Sarah, Birsen, Rudy, Larrue, Clément, Simonetta, Federico, Tamburini, Jerome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656606/
https://www.ncbi.nlm.nih.gov/pubmed/34885077
http://dx.doi.org/10.3390/cancers13235966

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