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Alphataxin, a Small-Molecule Drug That Elevates Tumor-Infiltrating CD4(+) T Cells, in Combination With Anti-PD-1 Therapy, Suppresses Murine Renal Cancer and Metastasis

By promoting the cytotoxic function of CD8(+) T cells, immune checkpoint inhibitor therapy, e.g. programmed cell death protein-1 (PD-1), effectively inhibits tumor growth in renal cell carcinoma. Yet, as many as 87% of cancer patients do not respond to immune checkpoint therapy. Importantly, cytotox...

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Detalles Bibliográficos
Autores principales:	Bristow, Cynthia L., Reeves, Mary Ann B., Winston, Ronald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656697/ https://www.ncbi.nlm.nih.gov/pubmed/34900690 http://dx.doi.org/10.3389/fonc.2021.739080

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