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The Role of Bitter Taste Receptors in Cancer: A Systematic Review

SIMPLE SUMMARY: Bitter taste receptors (TAS2Rs) are functionally expressed in various extra-oral cells eliciting non-gustatory functions. In the context of cancer, their functionality is less clear, despite growing interest in recent years. This is the first systematic review that summarizes the cur...

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Autores principales: Zehentner, Sofie, Reiner, Agnes T., Grimm, Christoph, Somoza, Veronika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656863/
https://www.ncbi.nlm.nih.gov/pubmed/34885005
http://dx.doi.org/10.3390/cancers13235891
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author Zehentner, Sofie
Reiner, Agnes T.
Grimm, Christoph
Somoza, Veronika
author_facet Zehentner, Sofie
Reiner, Agnes T.
Grimm, Christoph
Somoza, Veronika
author_sort Zehentner, Sofie
collection PubMed
description SIMPLE SUMMARY: Bitter taste receptors (TAS2Rs) are functionally expressed in various extra-oral cells eliciting non-gustatory functions. In the context of cancer, their functionality is less clear, despite growing interest in recent years. This is the first systematic review that summarizes the current knowledge on the role of TAS2Rs in cancer from different perspectives, from cellular mechanisms of cancer to sensory perception. Although the association between TAS2R-mediated bitterness sensitivity, dietary intake and cancer risk is so far inconclusive, the majority of studies provide evidence for the downregulated gene expression of some functional TAS2Rs in cancerous compared to non-cancerous cell lines and tissue samples. Additionally, the agonist-related activation and overexpression of TAS2Rs per se induced various anti-cancer effects, leading to the hypothesis that TAS2Rs impact carcinogenesis and could serve as a target in cancer therapy by interfering with typical capabilities of cancerous cells, known as the hallmarks of cancer. ABSTRACT: Background: Since it is known that bitter taste receptors (TAS2Rs) are expressed and functionally active in various extra-oral cells, their genetic variability and functional response initiated by their activation have become of broader interest, including in the context of cancer. Methods: A systematic research was performed in PubMed and Google Scholar to identify relevant publications concerning the role of TAS2Rs in cancer. Results: While the findings on variations of TAS2R genotypes and phenotypes and their association to the risk of developing cancer are still inconclusive, gene expression analyses revealed that TAS2Rs are expressed and some of them are predominately downregulated in cancerous compared to non-cancerous cell lines and tissue samples. Additionally, receptor-specific, agonist-mediated activation induced various anti-cancer effects, such as decreased cell proliferation, migration, and invasion, as well as increased apoptosis. Furthermore, the overexpression of TAS2Rs resulted in a decreased tumour incidence in an in vivo study and TAS2R activation could even enhance the therapeutic effect of chemotherapeutics in vitro. Finally, higher expression levels of TAS2Rs in primary cancerous cells and tissues were associated with an improved prognosis in humans. Conclusion: Since current evidence demonstrates a functional role of TAS2Rs in carcinogenesis, further studies should exploit their potential as (co-)targets of chemotherapeutics.
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spelling pubmed-86568632021-12-10 The Role of Bitter Taste Receptors in Cancer: A Systematic Review Zehentner, Sofie Reiner, Agnes T. Grimm, Christoph Somoza, Veronika Cancers (Basel) Systematic Review SIMPLE SUMMARY: Bitter taste receptors (TAS2Rs) are functionally expressed in various extra-oral cells eliciting non-gustatory functions. In the context of cancer, their functionality is less clear, despite growing interest in recent years. This is the first systematic review that summarizes the current knowledge on the role of TAS2Rs in cancer from different perspectives, from cellular mechanisms of cancer to sensory perception. Although the association between TAS2R-mediated bitterness sensitivity, dietary intake and cancer risk is so far inconclusive, the majority of studies provide evidence for the downregulated gene expression of some functional TAS2Rs in cancerous compared to non-cancerous cell lines and tissue samples. Additionally, the agonist-related activation and overexpression of TAS2Rs per se induced various anti-cancer effects, leading to the hypothesis that TAS2Rs impact carcinogenesis and could serve as a target in cancer therapy by interfering with typical capabilities of cancerous cells, known as the hallmarks of cancer. ABSTRACT: Background: Since it is known that bitter taste receptors (TAS2Rs) are expressed and functionally active in various extra-oral cells, their genetic variability and functional response initiated by their activation have become of broader interest, including in the context of cancer. Methods: A systematic research was performed in PubMed and Google Scholar to identify relevant publications concerning the role of TAS2Rs in cancer. Results: While the findings on variations of TAS2R genotypes and phenotypes and their association to the risk of developing cancer are still inconclusive, gene expression analyses revealed that TAS2Rs are expressed and some of them are predominately downregulated in cancerous compared to non-cancerous cell lines and tissue samples. Additionally, receptor-specific, agonist-mediated activation induced various anti-cancer effects, such as decreased cell proliferation, migration, and invasion, as well as increased apoptosis. Furthermore, the overexpression of TAS2Rs resulted in a decreased tumour incidence in an in vivo study and TAS2R activation could even enhance the therapeutic effect of chemotherapeutics in vitro. Finally, higher expression levels of TAS2Rs in primary cancerous cells and tissues were associated with an improved prognosis in humans. Conclusion: Since current evidence demonstrates a functional role of TAS2Rs in carcinogenesis, further studies should exploit their potential as (co-)targets of chemotherapeutics. MDPI 2021-11-23 /pmc/articles/PMC8656863/ /pubmed/34885005 http://dx.doi.org/10.3390/cancers13235891 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Zehentner, Sofie
Reiner, Agnes T.
Grimm, Christoph
Somoza, Veronika
The Role of Bitter Taste Receptors in Cancer: A Systematic Review
title The Role of Bitter Taste Receptors in Cancer: A Systematic Review
title_full The Role of Bitter Taste Receptors in Cancer: A Systematic Review
title_fullStr The Role of Bitter Taste Receptors in Cancer: A Systematic Review
title_full_unstemmed The Role of Bitter Taste Receptors in Cancer: A Systematic Review
title_short The Role of Bitter Taste Receptors in Cancer: A Systematic Review
title_sort role of bitter taste receptors in cancer: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8656863/
https://www.ncbi.nlm.nih.gov/pubmed/34885005
http://dx.doi.org/10.3390/cancers13235891
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