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Duration of Untreated Disorder and Cannabis Use: An Observational Study on a Cohort of Young Italian Patients Experiencing Psychotic Experiences and Dissociative Symptoms
Background: The Duration of Untreated Psychosis (DUP) is the time between the first-episode psychosis (FEP) and the initiation of antipsychotic treatment. It is an important predictor of several disease-related outcomes in psychotic disorders. The aim of this manuscript is investigating the influenc...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657003/ https://www.ncbi.nlm.nih.gov/pubmed/34886357 http://dx.doi.org/10.3390/ijerph182312632 |
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author | Ricci, Valerio Martinotti, Giovanni Ceci, Franca Chiappini, Stefania Di Carlo, Francesco Burkauskas, Julius Susini, Ottavia Luciani, Debora Quattrone, Diego De Berardis, Domenico Pettorruso, Mauro Maina, Giuseppe Di Giannantonio, Massimo |
author_facet | Ricci, Valerio Martinotti, Giovanni Ceci, Franca Chiappini, Stefania Di Carlo, Francesco Burkauskas, Julius Susini, Ottavia Luciani, Debora Quattrone, Diego De Berardis, Domenico Pettorruso, Mauro Maina, Giuseppe Di Giannantonio, Massimo |
author_sort | Ricci, Valerio |
collection | PubMed |
description | Background: The Duration of Untreated Psychosis (DUP) is the time between the first-episode psychosis (FEP) and the initiation of antipsychotic treatment. It is an important predictor of several disease-related outcomes in psychotic disorders. The aim of this manuscript is investigating the influence of cannabis on the DUP and its clinical correlates. Methods: During years 2014–2019, sixty-two FEP patients with and without cannabis use disorder (CUD) were recruited from several Italian psychiatric hospitals. The subjects were then divided into two groups based on the duration of the DUP and assessed at the beginning of the antipsychotic treatment and after 3 and 6 months, using the Positive and Negative Syndrome Scale (PANSS), the Global Assessment of Functioning (GAF) scale, and the Dissociative Experiences Scale (DES-II). Results: As expected, a longer DUP was associated with worse symptoms and cannabis use did not seem to affect the DUP, but both were related with more dissociative symptoms at onset and over time. Discussion: According to our study, cannabis use can be a predictor of FEP and DUP, and of disease outcome. However, several factors might influence the relationship between cannabis use and DUP. Preventing cannabis use and early diagnosis of psychotic disorders might impact the disease by reducing the persistence of symptoms and limiting dissociative experiences. |
format | Online Article Text |
id | pubmed-8657003 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-86570032021-12-10 Duration of Untreated Disorder and Cannabis Use: An Observational Study on a Cohort of Young Italian Patients Experiencing Psychotic Experiences and Dissociative Symptoms Ricci, Valerio Martinotti, Giovanni Ceci, Franca Chiappini, Stefania Di Carlo, Francesco Burkauskas, Julius Susini, Ottavia Luciani, Debora Quattrone, Diego De Berardis, Domenico Pettorruso, Mauro Maina, Giuseppe Di Giannantonio, Massimo Int J Environ Res Public Health Article Background: The Duration of Untreated Psychosis (DUP) is the time between the first-episode psychosis (FEP) and the initiation of antipsychotic treatment. It is an important predictor of several disease-related outcomes in psychotic disorders. The aim of this manuscript is investigating the influence of cannabis on the DUP and its clinical correlates. Methods: During years 2014–2019, sixty-two FEP patients with and without cannabis use disorder (CUD) were recruited from several Italian psychiatric hospitals. The subjects were then divided into two groups based on the duration of the DUP and assessed at the beginning of the antipsychotic treatment and after 3 and 6 months, using the Positive and Negative Syndrome Scale (PANSS), the Global Assessment of Functioning (GAF) scale, and the Dissociative Experiences Scale (DES-II). Results: As expected, a longer DUP was associated with worse symptoms and cannabis use did not seem to affect the DUP, but both were related with more dissociative symptoms at onset and over time. Discussion: According to our study, cannabis use can be a predictor of FEP and DUP, and of disease outcome. However, several factors might influence the relationship between cannabis use and DUP. Preventing cannabis use and early diagnosis of psychotic disorders might impact the disease by reducing the persistence of symptoms and limiting dissociative experiences. MDPI 2021-11-30 /pmc/articles/PMC8657003/ /pubmed/34886357 http://dx.doi.org/10.3390/ijerph182312632 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ricci, Valerio Martinotti, Giovanni Ceci, Franca Chiappini, Stefania Di Carlo, Francesco Burkauskas, Julius Susini, Ottavia Luciani, Debora Quattrone, Diego De Berardis, Domenico Pettorruso, Mauro Maina, Giuseppe Di Giannantonio, Massimo Duration of Untreated Disorder and Cannabis Use: An Observational Study on a Cohort of Young Italian Patients Experiencing Psychotic Experiences and Dissociative Symptoms |
title | Duration of Untreated Disorder and Cannabis Use: An Observational Study on a Cohort of Young Italian Patients Experiencing Psychotic Experiences and Dissociative Symptoms |
title_full | Duration of Untreated Disorder and Cannabis Use: An Observational Study on a Cohort of Young Italian Patients Experiencing Psychotic Experiences and Dissociative Symptoms |
title_fullStr | Duration of Untreated Disorder and Cannabis Use: An Observational Study on a Cohort of Young Italian Patients Experiencing Psychotic Experiences and Dissociative Symptoms |
title_full_unstemmed | Duration of Untreated Disorder and Cannabis Use: An Observational Study on a Cohort of Young Italian Patients Experiencing Psychotic Experiences and Dissociative Symptoms |
title_short | Duration of Untreated Disorder and Cannabis Use: An Observational Study on a Cohort of Young Italian Patients Experiencing Psychotic Experiences and Dissociative Symptoms |
title_sort | duration of untreated disorder and cannabis use: an observational study on a cohort of young italian patients experiencing psychotic experiences and dissociative symptoms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657003/ https://www.ncbi.nlm.nih.gov/pubmed/34886357 http://dx.doi.org/10.3390/ijerph182312632 |
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