Cell-of-Origin and Genetic, Epigenetic, and Microenvironmental Factors Contribute to the Intra-Tumoral Heterogeneity of Pediatric Intracranial Ependymoma

SIMPLE SUMMARY: Intra-cranial ependymoma (EPN) accounts for approximately 10% of pediatric brain tumors. The current therapeutic strategies have not significantly improved prognosis, which is still dismal in nearly 40% of patients. Major challenges for treatment are chemorefractoriness of EPN, tende...

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Detalles Bibliográficos
Autores principales: Servidei, Tiziana, Lucchetti, Donatella, Navarra, Pierluigi, Sgambato, Alessandro, Riccardi, Riccardo, Ruggiero, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657076/
https://www.ncbi.nlm.nih.gov/pubmed/34885210
http://dx.doi.org/10.3390/cancers13236100

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