Cargando…

Higher Accumulation of Visceral Adipose Tissue Is an Independent Risk Factor for Hepatocellular Carcinoma among Viral Hepatitis Patients with Non-Cirrhotic Livers

SIMPLE SUMMARY: Hepatocellular carcinoma (HCC) occurring in non-cirrhotic livers is often overlooked in clinical practice because the present HCC surveillance strategies usually focus only on patients with cirrhotic livers. This study aimed to determine the risk factors for HCC among viral hepatitis...

Descripción completa

Detalles Bibliográficos
Autores principales: Imai, Kenji, Takai, Koji, Miwa, Takao, Maeda, Toshihide, Hanai, Tatsunori, Shirakami, Yohei, Suetsugu, Atsushi, Shimizu, Masahito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657094/
https://www.ncbi.nlm.nih.gov/pubmed/34885089
http://dx.doi.org/10.3390/cancers13235980
_version_ 1784612431046115328
author Imai, Kenji
Takai, Koji
Miwa, Takao
Maeda, Toshihide
Hanai, Tatsunori
Shirakami, Yohei
Suetsugu, Atsushi
Shimizu, Masahito
author_facet Imai, Kenji
Takai, Koji
Miwa, Takao
Maeda, Toshihide
Hanai, Tatsunori
Shirakami, Yohei
Suetsugu, Atsushi
Shimizu, Masahito
author_sort Imai, Kenji
collection PubMed
description SIMPLE SUMMARY: Hepatocellular carcinoma (HCC) occurring in non-cirrhotic livers is often overlooked in clinical practice because the present HCC surveillance strategies usually focus only on patients with cirrhotic livers. This study aimed to determine the risk factors for HCC among viral hepatitis patients with non-cirrhotic livers. The findings of this study could be very useful in detecting HCC at an early stage, especially in patients with viral hepatitis who may not have developed extensive cirrhosis. ABSTRACT: This study aimed to determine the risk factors for hepatocellular carcinoma in non-cirrhotic livers among viral hepatitis patients. A total of 333 HCC cases, including 69 hepatitis B virus (HBV)-related and 264 hepatitis C virus (HCV)-related, were divided into cirrhotic (Fibrosis-4 [FIB-4] index > 3.25) and non-cirrhotic groups (FIB-4 index ≤ 3.25). The clinical characteristics of the two groups were compared. The independent risk factors for the development of HCC were analyzed using logistic regression analysis. The patients with HBV-related HCC were significantly younger, had better Child-Pugh scores, lower FIB-4 index and Mac-2 binding protein glycosylated isomers (M2BPGi) levels, more progressive cancer stage, and higher alpha-fetoprotein (AFP) levels than those with HCV-related HCC. Diabetes mellitus and hypertension were less common in patients with HBV-related HCC. The non-cirrhotic group with HBV-related HCC had a higher visceral adipose tissue index (VATI), better Child-Pugh score, and higher hemoglobin A1c (HbA1c), whereas the one with HCV-related HCC had a higher proportion of men, higher VATI, better Child-Pugh score, higher HbA1c, and a higher prevalence of hypertension, than the corresponding cirrhotic groups. Logistic regression analyses demonstrated that age, male sex, VATI, HbA1c, the presence of hypertension, and HBV etiology were independent risk factors for HCC in a non-cirrhotic liver. A high accumulation of VAT is a risk factor for HCC in patients with non-cirrhotic livers.
format Online
Article
Text
id pubmed-8657094
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-86570942021-12-10 Higher Accumulation of Visceral Adipose Tissue Is an Independent Risk Factor for Hepatocellular Carcinoma among Viral Hepatitis Patients with Non-Cirrhotic Livers Imai, Kenji Takai, Koji Miwa, Takao Maeda, Toshihide Hanai, Tatsunori Shirakami, Yohei Suetsugu, Atsushi Shimizu, Masahito Cancers (Basel) Article SIMPLE SUMMARY: Hepatocellular carcinoma (HCC) occurring in non-cirrhotic livers is often overlooked in clinical practice because the present HCC surveillance strategies usually focus only on patients with cirrhotic livers. This study aimed to determine the risk factors for HCC among viral hepatitis patients with non-cirrhotic livers. The findings of this study could be very useful in detecting HCC at an early stage, especially in patients with viral hepatitis who may not have developed extensive cirrhosis. ABSTRACT: This study aimed to determine the risk factors for hepatocellular carcinoma in non-cirrhotic livers among viral hepatitis patients. A total of 333 HCC cases, including 69 hepatitis B virus (HBV)-related and 264 hepatitis C virus (HCV)-related, were divided into cirrhotic (Fibrosis-4 [FIB-4] index > 3.25) and non-cirrhotic groups (FIB-4 index ≤ 3.25). The clinical characteristics of the two groups were compared. The independent risk factors for the development of HCC were analyzed using logistic regression analysis. The patients with HBV-related HCC were significantly younger, had better Child-Pugh scores, lower FIB-4 index and Mac-2 binding protein glycosylated isomers (M2BPGi) levels, more progressive cancer stage, and higher alpha-fetoprotein (AFP) levels than those with HCV-related HCC. Diabetes mellitus and hypertension were less common in patients with HBV-related HCC. The non-cirrhotic group with HBV-related HCC had a higher visceral adipose tissue index (VATI), better Child-Pugh score, and higher hemoglobin A1c (HbA1c), whereas the one with HCV-related HCC had a higher proportion of men, higher VATI, better Child-Pugh score, higher HbA1c, and a higher prevalence of hypertension, than the corresponding cirrhotic groups. Logistic regression analyses demonstrated that age, male sex, VATI, HbA1c, the presence of hypertension, and HBV etiology were independent risk factors for HCC in a non-cirrhotic liver. A high accumulation of VAT is a risk factor for HCC in patients with non-cirrhotic livers. MDPI 2021-11-28 /pmc/articles/PMC8657094/ /pubmed/34885089 http://dx.doi.org/10.3390/cancers13235980 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Imai, Kenji
Takai, Koji
Miwa, Takao
Maeda, Toshihide
Hanai, Tatsunori
Shirakami, Yohei
Suetsugu, Atsushi
Shimizu, Masahito
Higher Accumulation of Visceral Adipose Tissue Is an Independent Risk Factor for Hepatocellular Carcinoma among Viral Hepatitis Patients with Non-Cirrhotic Livers
title Higher Accumulation of Visceral Adipose Tissue Is an Independent Risk Factor for Hepatocellular Carcinoma among Viral Hepatitis Patients with Non-Cirrhotic Livers
title_full Higher Accumulation of Visceral Adipose Tissue Is an Independent Risk Factor for Hepatocellular Carcinoma among Viral Hepatitis Patients with Non-Cirrhotic Livers
title_fullStr Higher Accumulation of Visceral Adipose Tissue Is an Independent Risk Factor for Hepatocellular Carcinoma among Viral Hepatitis Patients with Non-Cirrhotic Livers
title_full_unstemmed Higher Accumulation of Visceral Adipose Tissue Is an Independent Risk Factor for Hepatocellular Carcinoma among Viral Hepatitis Patients with Non-Cirrhotic Livers
title_short Higher Accumulation of Visceral Adipose Tissue Is an Independent Risk Factor for Hepatocellular Carcinoma among Viral Hepatitis Patients with Non-Cirrhotic Livers
title_sort higher accumulation of visceral adipose tissue is an independent risk factor for hepatocellular carcinoma among viral hepatitis patients with non-cirrhotic livers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657094/
https://www.ncbi.nlm.nih.gov/pubmed/34885089
http://dx.doi.org/10.3390/cancers13235980
work_keys_str_mv AT imaikenji higheraccumulationofvisceraladiposetissueisanindependentriskfactorforhepatocellularcarcinomaamongviralhepatitispatientswithnoncirrhoticlivers
AT takaikoji higheraccumulationofvisceraladiposetissueisanindependentriskfactorforhepatocellularcarcinomaamongviralhepatitispatientswithnoncirrhoticlivers
AT miwatakao higheraccumulationofvisceraladiposetissueisanindependentriskfactorforhepatocellularcarcinomaamongviralhepatitispatientswithnoncirrhoticlivers
AT maedatoshihide higheraccumulationofvisceraladiposetissueisanindependentriskfactorforhepatocellularcarcinomaamongviralhepatitispatientswithnoncirrhoticlivers
AT hanaitatsunori higheraccumulationofvisceraladiposetissueisanindependentriskfactorforhepatocellularcarcinomaamongviralhepatitispatientswithnoncirrhoticlivers
AT shirakamiyohei higheraccumulationofvisceraladiposetissueisanindependentriskfactorforhepatocellularcarcinomaamongviralhepatitispatientswithnoncirrhoticlivers
AT suetsuguatsushi higheraccumulationofvisceraladiposetissueisanindependentriskfactorforhepatocellularcarcinomaamongviralhepatitispatientswithnoncirrhoticlivers
AT shimizumasahito higheraccumulationofvisceraladiposetissueisanindependentriskfactorforhepatocellularcarcinomaamongviralhepatitispatientswithnoncirrhoticlivers