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The Polymorphism at PLCB4 Promoter (rs6086746) Changes the Binding Affinity of RUNX2 and Affects Osteoporosis Susceptibility: An Analysis of Bioinformatics-Based Case-Control Study and Functional Validation

PURPOSE: Genome-wide association studies have identified numerous genetic variants that are associated with osteoporosis risk; however, most of them are present in the non-coding regions of the genome and the functional mechanisms are unknown. In this study, we aimed to investigate the potential var...

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Detalles Bibliográficos
Autores principales:	Tsai, Dung-Jang, Fang, Wen-Hui, Wu, Li-Wei, Tai, Ming-Cheng, Kao, Chung-Cheng, Huang, Shih-Ming, Chen, Wei-Teing, Hsiao, Po-Jen, Chiu, Chih-Chien, Su, Wen, Wu, Chia-Chun, Su, Sui-Lung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657146/ https://www.ncbi.nlm.nih.gov/pubmed/34899595 http://dx.doi.org/10.3389/fendo.2021.730686

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