GSK-3 Inhibition Is Cytotoxic in Glioma Stem Cells through Centrosome Destabilization and Enhances the Effect of Radiotherapy in Orthotopic Models

SIMPLE SUMMARY: High-grade gliomas remain difficult-to-treat cancers. Novel treatment options include targeting glycogen synthase kinase 3 (GSK-3) to induce cell death but the mode of drug activity remains unknown and combination with conventional treatment including radiotherapy has not been explor...

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Detalles Bibliográficos
Autores principales: Brüning-Richardson, Anke, Shaw, Gary C., Tams, Daniel, Brend, Tim, Sanganee, Hitesh, Barry, Simon T., Hamm, Gregory, Goodwin, Richard J. A., Swales, John G., King, Henry, Steele, Lynette, Morton, Ruth, Widyadari, Anastasia, Ward, Thomas A., Esteves, Filomena, Boissinot, Marjorie, Mavria, Georgia, Droop, Alastair, Lawler, Sean E., Short, Susan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657225/
https://www.ncbi.nlm.nih.gov/pubmed/34885051
http://dx.doi.org/10.3390/cancers13235939

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